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List of steroidal antiandrogens

Cyproterone acetate, the most well-known and widely used steroidal antiandrogen.
Steroid ring system.

This is a list of steroidal antiandrogens.

Progesterone derivatives

Testosterone derivatives

  • Abiraterone (CB-7598) = 17-(3-pyridinyl)androsta-5,16-dien-3β-ol
  • Abiraterone acetate = 17-(3-pyridinyl)androsta-5,16-dien-3β-ol acetate
  • Benorterone (SKF-7690, FC-612) = 17α-methyl-B-nortestosterone
  • BOMT (Ro 7-2340) = 6α-bromo-4-oxa-17α-methyl-4,5α-dihydrotestosterone
  • Delanterone (GBR-21162) = 17β-dehydroxy-1α-methyl-δ16-testosterone
  • Dienogest = 17α-cyanomethyl-19-nor-δ9(10)-testosterone
  • Epitestosterone = 17α-epitestosterone
  • Galeterone (TOK-001, VN/124-1) = 17-(1H-benzimidazol-1-yl)androsta-5,16-dien-3β-ol
  • Metogest (SC-14207) = 16,16-dimethyl-19-nortestosterone
  • Mifepristone = 11β-[p-(dimethylamino)phenyl]-17-(1-propynyl)-δ9-19-nortestosterone
  • Oxendolone (TSAA-291) = 16β-ethyl-19-nortestosterone
  • Rosterolone (SH-434, 17α-propylmesterolone) = 1α-methyl-17α-propyl-4,5α-dihydrotestosterone
  • Topterone (WIN-17665) = 17α-propyltestosterone
  • Trimethyltrienolone (R-2956, RU-2956) = 2α,2β,17α-trimethyl-19-nor-δ9,11-testosterone
  • Zanoterone (WIN-49596) = (5α,17α)-1'-(methylsulfonyl)-1'-H-pregn-20-yno[3,2-c]pyrazol-17-ol

Spirolactone derivatives

  • SC-5233 (spirolactone) = 17α-(2-carboxyethyl)testosterone γ-lactone
  • SC-8109 = 19-norspirolactone
  • Canrenone (aldadiene) = Δ6-spirolactone
  • Dicirenone (SC-26304) = 7α-carboxyisopropylspirolactone
  • Drospirenone = 6β,7β:15β,16β-dimethylenespirolactone
  • Mespirenone (ZK-94679) = Δ1-7α-acetylthio-15β,16β-methylenespirolactone
  • Mexrenone (ZK-32055, SC-25152) = 7α-(methoxycarbonyl)spirolactone
  • Prorenone (SC-23133) = 6α,7α-methylenespirolactone
  • Spironolactone = 7α-acetylthiospirolactone
  • Spirorenone (ZK-35973) = Δ1-6β,7β:15β,16β-dimethylenespirolactone
  • Spiroxasone = 7α-acetylthiospirolactone with the ketone group removed from the C17α spirolactone ring

Cortisol derivatives

Others

  • Guggulsterone = pregna-4,17-diene-3,16-dione
  • Nordinone = 11α-hydroxy-17,17-dimethyl-18-norandrosta-4,13-dien-3-one

See also