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List of opioids

Opium poppy (Papaver somniferum) flower

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products

Natural opiates

Opium alkaloids

Alkaloid salts mixtures

Semisynthetics including Bentley compounds

Morphine family

Structures of Morphine family
Morphine family
Chemical structure of 14-Hydroxymorphine.14-Hydroxymorphine Chemical structure of 2,4-Dinitrophenylmorphine.2,4-Dinitrophenylmorphine Chemical structure of 6-Methyldihydromorphine.6-Methyldihydromorphine Chemical structure of 6-Methylenedihydrodesoxymorphine.6-Methylenedihydrodesoxymorphine Chemical structure of 6-Acetyldihydromorphine hydrochloride.6-Acetyldihydromorphine hydrochloride
Chemical structure of Azidomorphine. Azidomorphine Chemical structure of Chlornaltrexamine. Chlornaltrexamine Chemical structure of Chloroxymorphamine. Chloroxymorphamine Chemical structure of Desomorphine.Desomorphine
(Dihydrodesoxymorphine)
Chemical structure of Dihydromorphine. Dihydromorphine
Chemical structure of Ethyldihydromorphine. Ethyldihydromorphine Chemical structure of Hydromorphinol. Hydromorphinol Chemical structure of Methyldesorphine. Methyldesorphine Chemical structure of N-Phenethylnormorphine. N-Phenethylnormorphine Chemical structure of 6-nicotinoyldihydromorphine.6-nicotinoyldihydromorphine
Chemical structure of RAM-378. RAM-378

3,6-diesters of morphine

Structures
3,6-diesters of morphine
Chemical structure of Acetylpropionylmorphine. Acetylpropionylmorphine 3,6-Dibutanoylmorphine Chemical structure of Diacetyldihydromorphine.Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Chemical structure of Dibutyrylmorphine. Dibutyrylmorphine Chemical structure of Dibenzoylmorphine. Dibenzoylmorphine Chemical structure of Diformylmorphine. Diformylmorphine
Chemical structure of Dipropanoylmorphine. Dipropanoylmorphine Chemical structure of Heroin.Heroin
(diacetylmorphine)
Chemical structure of Nicomorphine. Nicomorphine

Codeine-dionine family

Structures

Morphinones and morphols

Morphides

Structures
Morphides
Chemical structure of Αlpha-chlorocodide. α-chlorocodide Chemical structure of Beta-chlorocodide. β-chlorocodide Chemical structure of Bromomorphide. Bromomorphide
Chemical structure of Chlorodihydrocodide. Chlorodihydrocodide. Chemical structure of Chloromorphide. Chloromorphide Chemical structure of Codide. Codide

Dihydrocodeine series

Nitrogen morphine derivatives

Structures
Morphides
Chemical structure of 1-Nitrocodeine. 1-Nitrocodeine Chemical structure of Codeine-N-oxide. Codeine-N-oxide Chemical structure of Morphine-N-oxide. Morphine-N-oxide

Hydrazones

Structures
Hydrazones
Chemical structure of Oxymorphazone. Oxymorphazone

Halogenated morphine derivatives

Structures
Other open chain opioids
Chemical structure of 1-Bromocodeine.

1-Bromocodeine

Chemical structure of 1-Chlorocodeine.

1-Chlorocodeine

General structure of 1-Iodomorphine.

1-Iodomorphine

Active opiate metabolites

Morphinans

Morphinan series

Structures
Other Morphinans
Chemical structure of 4-chlorophenylpyridomorphinan 4-chlorophenylpyridomorphinan Chemical structure of Cyclorphan. Cyclorphan Chemical structure of Dextrallorphan. Dextrallorphan Chemical structure of Levargorphan Levargorphan Chemical structure of Levophenacylmorphan. Levophenacylmorphan
Chemical structure of Levomethorphan Levomethorphan Chemical structure of Norlevorphanol. Norlevorphanol Chemical structure of N-Methylmorphinan. N-Methylmorphinan Chemical structure of Oxilorphan. Oxilorphan Chemical structure of Phenomorphan. Phenomorphan
Chemical structure of Dextromethorphan. Dextromethorphan Chemical structure of Levomethorphan. Levomethorphan Chemical structure of Morphanol. Morphanol Chemical structure of Ro4-1539. Ro4-1539 Chemical structure of Stephodeline. Stephodeline Chemical structure of Xorphanol. Xorphanol

Others

Structures
Other Morphinans
Chemical structure of 1-Nitroaknadinine 1-Nitroaknadinine Chemical structure of 14-episinomenine. 14-episinomenine Chemical structure of 5,6-Dihydronorsalutaridine. 5,6-Dihydronorsalutaridine Chemical structure of 6-Keto Nalbuphine 6-Keto Nalbuphine Chemical structure of Aknadinine. Aknadinine
Chemical structure of Butorphanol Butorphanol Chemical structure of Cephakicine. Cephakicine Chemical structure of Cephasamine. Cephasamine Chemical structure of Cyprodime. Cyprodime Chemical structure of Drotebanol. Drotebanol
Chemical structure of Fenfangjine G. Fenfangjine G Chemical structure of Nalbuphine. Nalbuphine Chemical structure of Sinococuline. Sinococuline Chemical structure of Sinomenine. Sinomenine Chemical structure of Tannagine. Tannagine

Benzomorphans

4-Phenylpiperidines

Pethidines (meperidines)

Prodines

Ketobemidones

Others

Structures
Other phenylpiperidines
Chemical structure of Alvimopan.Alvimopan Chemical structure of Loperamide. Loperamide General structure of Picenadol. Picenadol

Open chain opioids

Amidones

Methadols

Structures
Other open chain opioids
Chemical structure of Alphaacetylmethadol.

Alphaacetylmethadol

Chemical structure of Dimepheptanol.

Dimepheptanol

General structure of Levacetylmethadol.

Levacetylmethadol

Chemical structure of Noracetylmethadol.

Noracetylmethadol

Moramides

Thiambutenes

Phenalkoxams

Ampromides

Structures

Others

Structures
Other open chain opioids
Chemical structure of embutramide.

Embutramide

Chemical structure of IC-26.

IC-26

Chemical structure of Isoaminile.

Isoaminile

General structure of Lefetamine.

Lefetamine

Chemical structure of R-4066.

R-4066

Anilidopiperidines

Oripavine derivatives

Thienorphine

Phenazepanes

Pirinitramides

Structures
Pirinitramides
Chemical structure of Bezitramide.

Bezitramide

Chemical structure of Piritramide.

Piritramide

Benzimidazoles

Structures
Benzimidazoles
Chemical structure of Clonitazene.

Clonitazene

Chemical structure ofEtonitazene.

Etonitazene

General structure of Nitazene .

Nitazene: R = Hydrogen

Indoles

Beta-Amino Ketones

Diphenylmethylpiperazines

Structures
Diphenylmethylpiperazines
Chemical structure of BW373U86.

BW373U86

Chemical structure of DPI-221.

DPI-221

Chemical structure of DPI-287.

DPI-287

Chemical structure of DPI-3290.

DPI-3290

Chemical structure of SNC-80.

SNC-80

Opioid peptides

Dynorphins

Structures

Endomorphins

Endorphins

Enkephalins

Propeptides

Others / unknown

Others

Opioid antagonists and inverse agonists

Biased ligands

Receptor heteromer targeting ligands

Uncategorized opioids

Combination drug formulations containing opioids

See also

References

  1. ^ ChemIndex CAS Registry Number 3371-56-0
  2. ^ ChemIndex CAS Registry Number 509-56-8
  3. ^ ChemIndex CAS Registry Number 63715-94-6
  4. ^ NCBI PubChem SID 750205
  5. ^ chembase[permanent dead link] cbid_346222
  6. ^ Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.
  7. ^ Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.

External links

  • Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740