This is a list of
notable , including both original immigrants who obtained American citizenship and their American descendants.
Americans of Spanish descent
There are also many people in the United States of Hispanic "national" origin, (
Cuban Americans, etc) or other Latin Americans, who self-identify their heritage as being from Spain.
The list also includes many settlers and descendants of Spanish settlers who lived in the Spanish colonies south of the current U.S. when those territories were incorporated into U.S. and to his inhabitants were given the U.S. citizenship (Louisiana is incorporated in 1803, Florida in 1819, and the Southwest was incorporated in 1848).
This list is ordered by surname within section.
To be included in this list, the person must have a Wikipedia article showing they are Spanish American or must have references showing they are Spanish American and are notable.
Artists and designers
Adela Akers (born February 7, 1933) – American textile artist born in Spain
Mabel Alvarez (1891–1985) – Prominent American artist
Carlos Baena – Spanish-born American employee in the Pixar studies
Federico Castellon (1914–1971) – painter and sculptor born in Almeria, Spain
Javier Cabada (born October 25, 1931) – Spanish-born American artist who paints colorful, abstract works
Beatriz Colomina (born 1952) – Spanish-born architecture historian
Julio de Diego (1900–1979) – Spanish-born American visual artist
Anh Duong (born October 25, 1960) – French-American artist, actress, and model, daughter of a Spanish mother and Vietnamese father.
John A. Garcia (born 1949) – Spanish-born entrepreneur and philanthropist. He is best known as a pioneer of the modern American computer game industry.
Frank Garcia (1927–1993)– American son of Spanish immigrants 
Xavier Gonzalez (1898–1993) – Spanish-born American artist.
Rafael Guastavino (1842–1908) – Spanish-born American architectural engineer.
Adele Morales (1925–2015) – American painter and memoirist. He is of Spanish and Peruvian descent.
Stephen Mopope (1898–1974) – Kiowa painter, dancer, and flute player of Spanish descent
Victor Moscoso (born 1936) – Psychedelic underground comix cartoonist, born in Galicia and raised in the US.
Esteban Munras (1798–1850) – 19th-century Spanish artist, probably best known for the vibrantly-colored frescoes that adorn the chapel interior at Mission San Miguel Arcángel in California.
Narciso Rodriguez, American fashion designer. Son of Cuban parents of Canarian (Spanish) descent 
Richard Serra (born November 2, 1938) – American sculptor. His father was Spanish native of Mallorca and mother was Russian, in Odessa 
Iñigo Manglano-Ovalle (born 1961) – Spanish American artist 
Urbici Soler i Manonelles (1890–1953) – American sculptor and art educator.
Wenceslao Moreno (1896–1999) – known to his American fans as "Senor Wences", Moreno was for decades a top ventriloquist in Spain, elsewhere in Europe, as well as in Latin America and the United States. In the US, he was a favorite in vaudeville and, later, television, especially on The Ed Sullivan Show. He was born in Salamanca and died at the age of 103 in New York City 
Faye Resnick (born July 3, 1957) – American television personality, author, and interior designer. He is of Spanish, Italian and English descent  
Eva Camacho-Sánchez – Spanish raised American fashion designer and maker who is focused in felted decorations, jewelry, housewares, and accessories at her company Lana Handmade.
Carmen Marc Valvo – fashion designer
Antonio Prieto (1912–1967) – Spanish-born American ceramic artist and art professor at Mills College, Oakland, California. He was instrumental in developing an important ceramics collection for the Mills College Art Museum. Kat Von D (born March 8, 1982) – Tattoo artist of European descent; Spanish ancestry from mom 
Micaela Almonester, Baroness de Pontalba (1795–1874) – wealthy New Orleans-born aristocrat, businesswoman and real estate developer, and one of the most dynamic personalities of that city's history.
John Arrillaga (born 1937) – real estate businessman.
John Casablancas (1942–2013) – American modeling agent and scout. He is credited for developing the concept of supermodel. His parents were Spanish, having escaped of Spain during the Spanish Civil War 
Manuel Lisa (1772–1820) – Spanish fur trader, explorer, and United States Indian agent. He was among the founders in St. Louis of the Missouri Fur Company, an early fur trading company, and he was also the first settlers of Nebraska 
Frank Lorenzo (born May 19, 1940) – airline executive who founded Continental Airlines. He is of Spanish parents 
Juan de Miralles - (1713-1780) Spanish-born arms dealer and messenger to the American Continental Congress.
Edward L. Romero (born January 2, 1934) – entrepreneur and American diplomat who served as the U.S. Ambassador to Spain and Andorra in 1998. His family was descended in part of the Spanish settlers who arrived to New Mexico in 1598 
Frank Stephenson (born October 3, 1959) – American automobile designer. He is son of a Norwegian father and a Spanish mother 
Andy Unanue – former vice president of Goya Foods
Joseph A. Unanue (1925–2013) – served 27-year tenure as president of Goya Foods, the largest Hispanic-owned food company in the United States
Rodolfo Valentin (born June 22, 1944) – New York City hairdresser and entrepreneur, to Italian and Spanish parents. Vicente Martinez Ybor (1818–1896) – Spanish-American industrialist and Cuban cigar manufacturer 
Screenwriter, Directors and Producers of film and television
Rafael Alvarez (born May 24, 1958) – American screenwriter. He is of Spanish partial descent 
Miguel Arteta (born 1965) – Puerto Rican director of film and television, known for his independent film (2000), for which he received the Chuck & Buck Independent Spirit John Cassavetes Award, and . He is of Peruvian father and Spanish mother Cedar Rapids 
Lisa Loomer – playwright and screenwriter of Spanish and Romanian ancestry 
George A. Romero (1940–2017) – American film director, screenwriter and film editor, best known for his series of zombie apocalypse, beginning with (1968). He was the son of a Night of the Living Dead Cuban-born father of Castilian Spanish parentage and a  Lithuanian American mother.
Jaume Collet-Serra (born March 23, 1974) – Spanish-born American film director and producer. Carles Torrens (born 1984) - Spanish-born film and television director, screenwriter, editor, and producer.
Actors and actresses
Luis Alberni (1886–1962) – Catalan actor
Maria Alba (1905–1999) – Spanish-born American film actress
Trini Alvarado (born January 10, 1967) – American actress, Puerto Rican Mother and Spanish father
Armida (1911–1989) – American actress, singer, dancer, and vaudevillian born in Mexico and of a Spanish father 
Tina Aumont (1946–2006) – American actress daughter of María Montez
Ariana Barouk – TV host, actress, model, and singer, who represented Cuba in the seventh edition of the environmentally oriented Miss Earth, International Beauty Pageant. His parents are Cubans of partially Spanish descent (her grandmother maternal was Spanish)
Joan Bennett (1910–1990) American stage, film and television actress. Her mother was actress Adrienne Morrison, daughter of actor Lewis Morrison, who was of English, Spanish, Jewish, and African ancestry  
Constance Bennett (1904–1965) - American actress sister of Joan Bennett
Barbara Bennett (1906–1958) - Actress/dancer sister of Joan and Constance Bennett
Maria Canals-Barrera (born September 28, 1966) - American actress, voice actress and singer of Catalan descent. 
Ouida Bergère (1886–1974) – Spanish father and English/French mother 
Carlos Bernard – American actor ( 24 (TV series)). His mother is from Madrid 
Paloma Bloyd (born in Chicago, Illinois) – American actress. His mother is from Spain
Fortunio Bonanova (1895–1969) – Spanish born baritone singer and a film, theater, and television actor.
Diego Boneta – American actor and singer. His father is Mexican, while his mother was born in the United States, to a Puerto Rican father and Spanish mother 
Richard Cansino – American voice actor and nephew of Rita Hayworth.
Tia Carrere – American Actress ( General Hospital, Relic Hunter). She is of Filipino, Chinese and Spanish descent 
Leo Carrillo (1881–1961) – actor, vaudevillian, political cartoonist, and conservationist. His great-great grandfather, José Raimundo Carrillo (1749–1809), was a Spanish settler of San Diego, California. 
Charisma Carpenter – American actress ( ) of mother of Cherokee and Spanish descent Buffy the Vampire Slayer 
Lynda Carter – actress and singer best known as the title character in popular 1970s television series . Her mother was of Wonder Woman Spanish and Mexican descent 
Darren Criss – American actor. His mother is Philippine of Chinese, Spanish, and Filipino descent 
Imogene Coca (1908–2001) – American actress, her father of Spanish descent.
Mark Consuelos – American actor, from Zaragoza, Spain
Mary Costa – American singer and actress, who is best known for providing the voice of Princess Aurora in the 1959 film, . Sleeping Beauty
Mark Dacascos – American actor and martial artist. His father is of Spanish partial descent.
Richard Davalos (1930–2016) – American actor of Finnish and Spanish descent 
Cameron Diaz – father was of Spanish-Cuban descent 
Héctor Elizondo – born in New York City, the son of Spanish ( Basque)- Puerto Rican parents 
Joe Estevez- actor and Martin Sheen's brother, Spanish father
Emilio Estevez – American actor, director, writer. Spanish paternal grandfather, from Galicia, Spain.
Ramón Estévez – American actor, son of Martin Sheen
Renée Estévez – American actress, daughter of Martin Sheen
Mel Ferrer (1917–2008) – American actor, director of stage and screen and film producer. Cuban father of Spanish descent 
Santino Fontana – American actor, director, and composer, widely known for playing Greg on the television show . He is one quarter Spanish descent Crazy Ex-Girlfriend 
Trixie Friganza (1870–1955) – American actress of Spanish and Irish parents
Martin Garralaga (1894–1981) – Spanish-born film and television actor who portrayed more than 200 roles in film and television
Dominik Garcia-Lorido – American actress who has maternal Spanish-Austrian descent
Jesse Garcia – actor. His parents are Mexican and Spanish descent 
Joanna García – mother of Spanish descent    
William Gaxton (1893–1963) – American actor of film and theater.
Greg Giraldo (1965–2010) – American stand-up comic 
Lita Grey (1908–1995)- American actress. her mother's family was descended from a Californian Spanish family  
Myrtle Gonzalez (1891–1918) – American silent film actress. Spanish father 
Pedro Gonzalez-Gonzalez (1925–2006) – American character actor best known for his appearances in a number of John Wayne movies. He was the son of a Mexican American father and a Spanish mother 
Camille Guaty – family is originally from the Canary Islands 
Lena Hall – American actress and singer.
Salma Hayek – of Lebanese and Spanish-Mexican descent  
Rita Hayworth (1918–1987) – American actress and icon. His father was Spanish dancer Eduardo Cansino, Sr., born in Seville, Spain 
Tom Hernández (1915–1984) – American actor whose characters were always secondary  
Pepe Hern (1927–2009) – American actor whose characters, usually Spanish and Latin, were always secondary. He was brother of Tom Hernández.
Gaby Hoffmann – American actress. Father is of Spanish and Puerto Rican descent.
Paz de la Huerta – indie actress and muse of Zac Posen 
Vanessa Hudgens – actress and American singer. Her father is an American of Irish and Amerindian descent and her mother is Filipino of Chinese, Filipino and Spanish descent 
Celina Jade – actress, singer and martial artist.
Lainie Kazan (born May 15, 1940) – American actress and singer of half Spanish Sephardic ancestry.
Dorothy Lamour (1914–1996) – actress of French, Irish and Spanish descent 
Liza Lapira – American actress of Filipino, Spanish, and Chinese descent.
Jeanie MacPherson (1886–1946) – American actress, writer, and director from 1908 until the late 1940s. She was of Spanish, Scottish, and French descent 
Roma Maffia American actress of German, Spanish, English, and Afro-Caribbean descent 
Adele Mara (April 28, 1923 – May 7, 2010) – American actress, active in the mid 20th-century.
A Martinez – American actor of Native American, Spanish, and Mexican descent 
Velia Martinez (1920–1993) – actress, singer and former nightclub dancer.
Patricia Medina (1919–2012) – English-born American actress. His father was a Spanish immigrant of Canary Island and his mother was English.
Beryl Mercer (1882–1939) – Spanish born American actress of stage and screen who was based in the United States
Lea Michele – actress and singer; Has a Sephardi Jewish father (from a family from Spain and Turkey) and an Italian-American Catholic mother; Michele was raised Catholic 
Alfred Molina – English born American naturalized He is of Spanish and Italian descent  
Ricardo Montalbán (1920–2009) – Mexican radio, television, theatre and film actor to Spanish immigrants parents 
Carlos Montalbán – Mexican actor brother of Ricardo Montalbán
Amber Montana – American actress. Montana is of Cuban and Spanish descent  
Maria Montez (1912–1951) – Dominican actress of Canarian father 
Yolanda "Tongolele" Montes – exotic dancer and American actress of the Cinema of Mexico. Her father was Spanish/Swedish, her mother French/English.
Antonio Moreno (1887–1967) – Spanish-born American educated actor; he was a leading silent film star of the 1920s.
Frank Morgan (1890–1949) – American actor of German and Spanish ancestry. 
Morris W. Morris (1845–1906) – stage actor & Civil War soldier of the Louisiana Native Guards.
Adrienne Morrison – American actress, daughter of actor Lewis Morrison, who was of English, Spanish, Jewish, and African ancestry.
Kenny Morrison – American actor. He is of Irish, Spanish, and Filipino ancestry.
Frankie Muniz – actor ( Malcolm in the middle) and racecars driver. His father is Puerto Rican of Asturian (Spanish) descent
Dylan O'Brien – Spanish maternal great-grandmother 
Margaret O'Brien – child actress, Spanish mother.
Nia Peeples – American actress, whose mother is a Filipino of Filipino, German, French and Spanish descent 
Carlos Pena Jr. – American actor ( Big Time Rush), singer, and dancer. His father is of Spanish and Venezuelan descent, while his mother is of Dominican descent 
Julio Perillán – American actor of Spanish parents 
Lou Diamond Phillips – American actor. His mother descends partly from Spanish 
Anita Pomares, better known as Anita Page – was an American film actress primarily in the 1920s and 1930s and later 
Monica Ramon – American actress born in Spain.
Nathalia Ramos – actress and singer. Spanish father, Sephardi Jewish mother. Played a leading role, Yasmin, in . Bratz: The Movie
Monica Rial – American voice actress, script writer, and ADR director affiliated with Funimation and Seraphim Digital/Sentai Filmworks. His father is from Galicia, Spain.
Robert Ri'chard – He is of Louisiana Creole (French, African American, Native American, and Spanish) descent
Génesis Rodríguez – American actress. She is the daughter of Venezuelan singer and actor José Luis Rodríguez. Her grandfather is from Canary Islands.
Ned Romero – American actor and opera singer. His ancestry is He is of Chitimacha Native American, Spanish and French descent 
Anthony Ruivivar – American actor 
April Scott – American actress and model. She is of Spanish partially descent 
Marin Sais – American actress of the silent film era. She is descended of early Castilian settlers of California's colonial 
Reni Santoni – American film, television and voice actor. Santoni is of French and Spanish descent Sarah Shahi – actress and American model of Spanish mother  
Martin Sheen – Born 'Ramón Gerardo Antonio Estévez', father from Galicia, Spain. 
Charlie Sheen – American actor, Spanish paternal grandfather
Margarita Sierra (January 5, 1936 – September 6, 1963) – Spanish born American actress.
Henry Silva – American film and television actor of Spanish and Sicilian descent. 
Chrishell Stause – of both Japanese and Spanish descent.
Chuti Tiu – American actress of Chinese, Filipina and Spanish descent
Celeste Thorson – American actress, model, screenwriter, and activist of Lebanese, Spanish, Apache (Native American) and South Korean descent.
Bitsie Tulloch – mother of Spanish descent. 
Alanna Ubach – American actress of Spanish descent.
Elena Verdugo – 1940s Spanish-American actress.
Carlos PenaVega – American Film and TV actor, singer-songwriter, dancer and television show host. His father is of Spanish and Venezuelan descent, while his mother is of Dominican descent. 
Charlyne Yi – American actress, comedian, musician, writer, and painter. Her mother, a native of the Philippines, is of Filipino and Spanish descent 
Michael Wayne (1934–2003) – American film producer and actor, and the eldest son of actor John Wayne and his first wife, Josephine Alicia Saenz, who was of Spanish descent.
Patrick Wayne – actor, the second son of John Wayne and Josephine Alicia Saenz.
Donna Wilkes – American film actress known for her roles in several films, to Spanish/French mother and Irish father. Mikaela Hoover – American actress of Iranian, Italian and Spanish descent 
Esperanza Spalding – jazz singer and composer. 
David Archuleta – father of Spanish (Basque) descent.
Leonardo Balada – Spanish composer.
Cedric Bixler-Zavala – rock singer of predominantly European descent has Spanish ancestry from father.
Fortunio Bonanova (1895–1969) – who was a baritone singer and a film, theater, and television actor. He occasionally worked as a producer and director.
Eduardo Cansino, Sr. (1895–1968) – Flamenco dancer and Spanish actor. Father of Rita Hayworth.
Julian Casablancas – vocalist and songwriter of the New York band The Strokes. 
Al Cisneros – American musician from San Jose, California. He is the singer and bassist for the legendary stoner metal band Sleep
Nichole Cordova – singer and dancer. Cordova is a member of the musical group Girlicious.
Darren Criss – American actor, singer-songwriter, multi-instrumentalist, and composer. His Philippine mother is of Spanish partial descent. 
Xavier Cugat (1900–1990) – conductor, American Catalan artist and entrepreneur. He was a key figure in the spread of Latin music in the United States popular music. 
Charo – Spanish-American actress, comedian and Flamenco guitarist. She is best known for her exuberant stage presence and provocative outfits.
Chick Corea – American jazz and fusion pianist, keyboardist, and composer. He is of southern Italian and Spanish descent.  
Jonny Diaz – American contemporary Christian pop artist and brother of Matt Diaz. His grandfather who had emigrated from Barcelona. 
Vernon Duke (1903–1969) – American composer/songwriter, born into a noble family of mixed Georgian-Austrian-Spanish-Russian descent, en Belarus.
Gloria Estefan – Mothers parents were born in Pola de Siero, Asturias and Logroño, La Rioja, Spain .  
Joe Falcón (1900–1965) – American accordionist descendant of Cajuns and Spanish settlers (Isleños) of Louisiana. He was the first person recording a song and a Cajun music album.
Lilian García -American singer and ring announcer born in Spain. Spanish descent via Puerto Rico.
Jerry Garcia – guitarist and singer for the Grateful Dead. Father was born in La Coruña, Spain. 
Synyster Gates - American musician, best known for being the lead guitarist of the band Avenged Sevenfold. He is of Spanish and German descent.
Claudio S. Grafulla (1812–1880) - Spanish-born composer in the United States during the 19th Century, most noted for martial music for regimental bands during the early days of the American Civil War
Emilio de Gogorza – (1874–1949) American baritone.
Safeway Goya – singer of The Nobodys, who released an album on Capitol Records and EMI International August 8, 1984.
Scott Herren – music producer. His father is Catalan and his mother is Irish and Cuban. 
Eric Himy – American-born classical pianist of French-Spanish-Moroccan descent
Julio Iglesias – Spanish-born singer with American citizenship.
Enrique Iglesias – Grammy Winning Spanish pop singer songwriter. Spanish father ( Julio Iglesias) and Spanish Filipina mother ( Isabel Preysler)
José Iturbi (1895–1980) – Spanish conductor, harpsichordist and pianist.
Jeanette (singer) – London-born, American-raised singer. She is of Canarian and Maltese descent. 
Chris Kirkpatrick – American singer, dancer, and voice actor who is best known as a founding member of the pop group 'N Sync. He is of Irish, Scottish, Spanish and Indian descent.
Joseph Lacalle (1860–1937) – Spanish born American clarinetist, composer, conductor and music critic.
Kirstin Maldonado – American singer. Her mother is Spanish-Italian
Jim Martin (born 1961) – former guitarist of Faith No More
Bruno Mars – American singer-songwriter and record producer. Mars' mother immigrated to Hawaii from the Philippines as a child, and is of Filipino and some Spanish descent. Mars' father is of Puerto Rican and Ashkenazi Jewish descent.  
Mikaila – American singer of French, Mexican (Aztec) and Spanish descent.
Chino Moreno – American musician. He is children to a Spanish-Mexican father and a Spanish/ Chinese mother; 
Alcide Nunez (1884–1934) – Isleño American jazz clarinetist.
Kenny Ortega – Emmy-award-winning producer, director and choreographer. Most known for directing the High School Musical series and Michael Jackson's . Spanish grandparents. This Is It 
Franky Perez – American musician best known as a solo artist, singer of Finnish Cello-based rock band Apocalyptica. Son of Spanish and Cuban immigrants.
Irvan Perez (1923–2008) – Isleño singer. 
Manuel Perez (musician) (1871–1946) – American cornetist and bandleader born into a Creole of Color family of Spanish, French and African descent.
Achille Rivarde (1865–1940) – American-born British violinist and teacher.
Andy Russell (September 16, 1919 – April 16, 1992) – American popular vocalist to Mexican parents of Spanish descent.
Jessica Sanchez – American singer-songwriter
Paul Sanchez – American guitarist and a singer-songwriter. He was a founding member of the New Orleans band Cowboy Mouth, guitarist and one of the primary singers and songwriters for the band from 1990 to 2006. His father was an Isleño of Saint Bernard Parish, Louisiana.
Matthew Santos – rock and folk singer-songwriter, musician and painter, father of part-Spanish descent. 
Carly Simon – American singer-songwriter, musician, and children's author. Her mother is of Spanish and half Swiss descent.
Lucy Simon – American composer for the theatre and popular songs. Sister of Carly Simon.
Joanna Simon (mezzo-soprano) – sister of Carly and Lucy Simon.
Mariee Sioux – American folk singer-songwriter. Her father Gary Sobonya is a mandolin player of Polish and Hungarian descent, and her mother Felicia is of Spanish, Paiute, and Indigenous Mexican descent.
John Philip Sousa (1854–1932) – American composer and conductor of the late Romantic era, known primarily for American military and patriotic marches. His father was of Portuguese and Spanish ancestry.   
Malu Trevejo – Cuban-American singer of Cuban and Spanish descent.
Anton Torello – Catalan born American double bass player.
Camile Velasco – Filipino American singer and came in ninth place on the third season of the reality/talent-search television series, American Idol. She is of Irish, Spanish, and Filipino descent. 
Jaci Velasquez – descends of Spanish and Mexican settlers in Texas and French, Scottish, and Arabs immigrants. 
Camille Zamora – American soprano, Spanish ancestry on her father's side Samuel Arredondo (born 2002) – Californian-born singer who mostly works in his mother's country of the Republic of Korea where he has been on Produce 101 Season 2.
María Benítez – American dancer, choreographer and director in Spanish dance and flamenco
Carmencita – Spanish-born American-style dancer in American pre-vaudeville variety and music-hall ballet Joaquín De Luz – Spanish ballet dancer. He was formerly with the American Ballet Theatre (ABT), and currently, a principal dancer with the New York City Ballet (NYCB).
Barry Alvarez – American football coach. His grandparents immigrated to the United States from Northern Spain. 
Lyle Alzado (1949–1992) – professional American football defensive end of the National Football League. His father is of Italian-Spanish descent. 
Art Aragon (1927 – 2008) - American boxer
Jonathan Borrajo – American soccer player of Spanish parents. 
Gene Brito (1925–1965) – American football Defensive end in the National Football League. He was of Spanish and Mexicans parents.
Pete Carril – American former basketball coach.
Matt Diaz – American professional baseball outfielder for the Miami Marlins of Major League Baseball. His brother is Jonny Diaz. His grandfather who had emigrated from Barcelona. 
Mary Joe Fernández – professional tennis player and two-time Olympic gold medal winner. Father from Spain. 
Santiago Formoso – Spanish-American soccer defender who spent five seasons in the North American Soccer League.
Lefty Gomez – born Vernon Louis Gomez, New York Yankees Hall of Fame pitcher. 
Keith Hernandez - MVP-winning baseball player, grandfather from Málaga, Spain.
Manuel Hernandez - Spanish-American soccer player. Born in Spain.
Chris Gimenez - American professional baseball catcher for the Oakland Athletics
Al López – Hall-of-Fame baseball player and manager. Spanish parents. 
Mike Lowell – Puerto Rican former professional baseball third baseman in Major League Baseball. His parents were born in Cuba, and are of Irish and Spanish ancestry.
Malia Jones – American model and surfer. She is of Spanish-Filipino partially descent. 
David López-Zubero – former college and international swimmer who competed in three Summer Olympics and won an Olympic bronze medal.
Martin López-Zubero – American born, Spanish Olympian swimmer with dual-citizenship. His father is Spanish 
Saoul Mamby – former professional boxer of Spanish and Jamaica descent. 
Alec Martinez – American professional ice hockey player. His paternal grandfather is Spanish. 
Rachel McLish – American female bodybuilding champion, actress and author. Her father was of Spanish ancestry. 
Kimmie Meissner – former competitive figure skater. Her maternal great-grandparents were Spanish immigrants (great-grandfather was from Galicia). 
Midajah – American personal trainer, fitness model and former professional wrestling manager. He is the eldest of four children and is of Norwegian, Irish, Spanish, and French descent.
Lou Molinet (1904–1976) – first Hispanic-American professional football player to play in the National Football League.
Lou Piniella – baseball player and manager, Asturian grandparents 
Hernando Planells – assistant coach of the Maine Red Claws of the NBA Development League and former head coach of the Basketball Japan League (BJ) team Ryukyu Golden Kings.
Augusto Perez – former wheelchair curler.
Tony La Russa – baseball player and manager, born to Spanish and Italian parents in Ybor City in Tampa Florida. 
Ralph Onis (1908 in Tampa, Florida–1995) – professional baseball.
Jack Del Rio – American head coach of the Oakland Raiders of the National Football League (NFL), to a father of Spanish and Italian descent. 
Rich Rodriguez – Arizona head football coach. 
Fabri Salcedo (1914 in Santander, Cantabria, Spain–1985 in Rochelle Park, New Jersey) – soccer forward.
Wendy Lucero-Schayes – American former Olympic diver.
Craig Torres (bodybuilder)
Benny Urquidez – kickboxer, martial arts choreographer and actor. His father is descended from Basque Spaniards and Blackfoot Amerindians 
Alejandro Villanueva – offensive tackle, Pittsburgh Steeleers. Parents were born in Spain.
Minh Vu – American soccer player of Spanish and Vietnamese descent. Ted Williams (1918–2002) – American professional baseball player, manager, and World War II and Korean War veteran. His mother was of Spanish ( Basque), Russian, and American Indian descent. 
Military (excluding those who were also governors and politicians)
Santiago Argüello (1791–1862) – soldier in the Spanish army of New Spain in Las Californias, a major Mexican land grant ranchos owner, and part of an influential family in Mexican Alta California and post-statehood California. He was son of Spanish soldier José Darío Argüello 
Terry de la Mesa Allen, Sr. (1888–1969) – Major General, U.S. Army. Decorated World War II Division commander. Allen's maternal grandfather was Spanish Colonel Carlos Alvarez de la Mesa, who fought at Gettysburg for the Union Army in the Spanish Company of the 39th New York Volunteer Infantry Regiment, during the American Civil War.  Terry de la Mesa Allen Jr. (1929–67) – Lieutenant Colonel, U.S. Army. Killed in Vietnam War.
Pierre G. T. Beauregard (1818–1893) American military officer, politician, inventor, writer, civil servant, and the first prominent general of the Confederate States Army during the American Civil War. He was born in a Criole family of France and Spanish descent.
Santos Benavides (1823–1891) – confederate colonel in the American Civil War. He is descendant of Don Tomas Sanchez, the Spanish founder of Laredo, Texas.
Rudolph B. Davila (April 27, 1916 – January 26, 2002) – United States Army officer, of Spanish-Filipino descent who received the Medal of Honor for his actions in Italy during World War II. 
Luis F. Emilio (December 22, 1844 – September 16, 1918) – captain in the 54th Massachusetts Volunteer Infantry, an American Civil War Union regiment.
Jorge Farragut (1755–1817) – Spanish officer Navy who fought for the American War of Independence. Father of David Farragut.
David Farragut (1801–1870) – first senior officer of the U.S. Navy during the Civil War. Coined phrase "Damn the torpedoes, full speed ahead!". His father was the Spanish officer Navy Jorge Farragut 
John Horse (ca. 1812–1882) – African-American military adviser to the chief Osceola and a leader of Black Seminole units fighting against United States (US) troops during the Seminole Wars in Florida. He was a Seminole slave of Spanish, Seminole, and African American descent.
Baldomero Lopez (1925–1950) – first lieutenant in the United States Marine Corps during the Korean War. 
Louis Gonzaga Mendez, Jr. (1915–2001) – highly decorated United States Army officer of the 82nd Airborne Division who in June 1944, as commander of the 3rd Battalion, 508th Parachute Infantry Regiment during World War II, parachuted behind enemy lines into Normandy and was awarded a Distinguished Service Cross for leading an attack that captured the French town of Prétot-Vicquemare, in the Seine-Maritime department. He is descendant of Mexicans, Spanish and Navajo people.
Juan Moya (1806–1874) – prominent Tejano landowner and Mexican army´s captain who fought in the Texas Revolution. He was of Canarian descent.
John Ortega – first Hispanic sailor to be awarded the United States' highest military decoration for valor in combat – the Medal of Honor – for having distinguished himself during the South Atlantic Blockade by the Union Naval forces during the American Civil War.
Elwood Richard Quesada (1904–1993) – United States Air Force General, FAA administrator, and, later, a club owner in Major League Baseball. He was of Irish and Spanish descent.
Maritza Sáenz Ryan – United States Army officer, and the head of the Department of Law at the United States Military Academy. She is the first woman and first Hispanic West Point graduate to serve as an academic department head. She is daughter of a Puerto Rican father and Spanish mother.  Manuel Antonio Santiago Tarín (1811–1849) – Tejano soldier and a recruiter and participant in the Texas Revolution on the Texian side. His father was a Spanish officer.
Governors and politicians
Julian A. Chavez (1808–1879) – rancher, landowner and elected official in early Los Angeles, California, who served multiple terms on the Los Angeles Common Council (the forerunner to the present-day City Council) and the Los Angeles County Board of Supervisors.
Rafael Anchia – Democratic member of the Texas House of Representatives. His father is a Spanish Basque.
Jerry Apodaca – Democratic Governor of New Mexico (1974–78).
Polly Baca – American politician who served as Chair the Democratic Caucus of the Colorado House of Representatives (1976–79), being the first woman to hold that office, and the first Hispanic woman elected to the Colorado State Senate. She is a descendant of Spanish and Mexican settlers of New Mexico and Colorado, arrived there in the colonial period. 
Charles Dominique Joseph Bouligny (1773–1833) – lawyer and politician. He was U.S. Senator from Louisiana between 1824 and 1829. He was son of Francisco Bouligny. 
Dionisio Botiller (1842–1915) - elected a member of the Los Angeles, California, Common Council, the governing body of the city. Botiller's Spanish-heritage family settled in California in the 18th Century, living near Santa Barbara. 
Kate Brown – Democratic Governor of Oregon since 2015.
Carlos Lopez-Cantera – Republican politician from Miami, who served in the Florida House of Representatives before being appointed the 19th Lieutenant Governor of Florida (2014-2018)
Carlos Antonio Carrillo (1783–1852) – Governor of Alta California, (1837–1838)
José Antonio Carrillo (1796–1862) – Californio ranchero, official and political. He was mayor of Los Angeles, California (1826, 1828, and 1833).
Juan José Carrillo (1842–1916) – first mayor of Santa Monica, California
Pedro Casanave (?–1796?) – Spanish merchant who became the Master Masonic and fifth mayor of Georgetown (modern Washington DC). Casanave is particularly remembered for having buried the first stone in what later became the White House, on October 12, 1792.
Ezequiel Cabeza De Baca (1864–1917) – first Hispano elected for office as Lieutenant Governor in New Mexico's first election. He was a descendant of the original Spanish settlers which later became part of the Baca Family of New Mexico.
Dennis Chavez (1888–1962) – Democratic U.S. Senator from the State of New Mexico.
Linda Chavez – father's family came to New Mexico from Spain in 1601. 
Henry Cisneros – politician and businessman  Page Cortez (born 1961) – businessman from
Lafayette, Louisiana, who is a Republican member of the Louisiana State Senate from District 23.
Ted Cruz – U.S. Senator from Texas since 2013. His father is the Cuban son of a Spanish father from the Canary Islands
Manuel Dominguez (1804–1882) – Mayor of Los Angeles (1832). He was of Spanish settlers descent. 
Albert Estopinal (1845–1919) – sugar cane planter from St. Bernard Parish, Louisiana, who served as a Democrat in both houses of the Louisiana State Legislature between 1876 and 1900 and in the United States House of Representatives from Louisiana's 1st congressional district from 1908 until his death. Their ancestors came from the Canary Islands, Spain. 
Albert Estopinal, Jr. (1869–1952) – Attorney and politician from St. Bernard Parish in south Louisiana. He was son of Albert Estopinal.
José Joaquín Estudillo (1800–1852) – second alcalde of Yerba Buena, California (the precursor to San Francisco), and whose land holdings, known as Rancho San Leandro, formed the basis of the city of San Leandro. 
Joachim Octave Fernández (1896–1978) – member of the U. S. House of Representatives representing the state of Louisiana. He was a Democrat.
Fernando Ferrer – Borough President of The Bronx from 1987 to 2001, and was a candidate for Mayor of New York in 2001 and the Democratic Party nominee for Mayor in 2005
Bernardo de Gálvez (July 23, 1746 – November 30, 1786) – Spanish military leader and colonial administrator who served as colonial governor of Louisiana and Cuba, and later as Viceroy of New Spain. The US Senate passed, in December 2014, the granting of Honorary citizenship to Bernardo de Galvez, because he aided the American Thirteen Colonies in their quest for independence and led Spanish forces against Britain in the Revolutionary War. 
Antonio Maria de la Guerra (1825–1881) – Mayor of Santa Barbara, California, several times a member of the Santa Barbara County Board of Supervisors, California State Senator and Captain of California Volunteers in the American Civil War. He was son of Spanish soldier José de la Guerra y Noriega. 
José Gonzáles – American politician who served as first Mayor of Gonzales, Louisiana, between 1922/28 and 1932, and is considered the best mayor of that village. 
Joseph Marion Hernández (1793–1857) – American politician, plantation owner, and soldier. He was the first Delegate from the Florida Territory, becoming the first Hispanic American to serve in the United States Congress. His parents were Spanish settlers of St. Augustine in what was then East Florida. 
Vito Lopez - American politician, former member of the New York State Assembly.
Manuel Lujan Jr - Republican Congressman from New Mexico & Secretary of Interior.
Francisco Antonio Manzanares (1843–1904) – businessman and politician.
Luis H. Marrero (1847–1921) – chief of police in Jefferson Parish in New Orleans, president of parish's government between 1884 and 1916 and senator from Louisiana from 1892 to 1896. He was descend of Spanish settlers from Canary Island. 
Bob Martinez – former and first Hispanic Governor of Florida, grandson of Spanish immigrants.
Antonio Menchaca - (1800 – 1879) Mayor of San Antonio, Texas (1838 - 1839) y military who fought in the Texas Revolution. He was a Tejano whose parents were of Spanish descent.  His great-great grandfather was one of the founders and early settlers of Béxar.  
Joseph Montoya (1915–1978) – Democratic U.S. Senator from the State of New Mexico.
Francisco Portusach Martínez (1864–1919) – Spanish merchant and whaler who was briefly the Governor of Guam, before he was deposed.
Ramón Músquiz (1797–1867) – governor of Mexican Texas from 1830 to 1831 and 1835.
Antonio Narbona (1773–1830) – Spanish soldier born in Mobile, now in Alabama, when this belonged to Spanish Louisiana. He was Governor of Santa Fe de Nuevo México between September 1825 and 1827 and he fought Native American people in the northern part of Mexico (now the southwestern United States) around the turn of the nineteenth century. He was of Spanish descent pure 
Sammy Nunez – Louisiana politician of Canarian, or Isleño descent. 
Samuel B. Nunez, Jr. – politician and businessman from St. Bernard Parish, Louisiana. He is son of Sammy Nunez.
Miguel Antonio Otero (born 1829) – Spanish politician of the New Mexico Territory.
Miguel Antonio Otero (born 1859) – Governor of New Mexico Territory (1897–1906).
Mariano S. Otero (1844–1904) – delegate from the Territory of New Mexico.
Leander Perez (1891–1969) – Louisiana judge and politician of Isleño descent.
Pío Pico (1801–1894) – last Governor of Alta California under Mexican rule. He was of Native American, Spanish and African mixed-race ancestry.
Andrés Pico (1810–1876) – Californio rancher, military commander and was elected to the state assembly and senate after California became a state. Andrés Pico was the younger brother of Pío Pico
Sean Reyes – 21st Attorney General of Utah. He was appointed by Governor Gary Herbert following the resignation of John Swallow. His father was an immigrant from the Philippines of both Filipino and Spanish descent. 
Bill Richardson – American politician, who served as the 30th Governor of New Mexico from 2003 to 2011. His mother is the Mexican daughter of a Spanish father from Villaviciosa, Asturias (Spain) and a Mexican mother 
Junior Rodriguez – politician from St. Bernard Parish, Louisiana, of Isleño descent.
Ken Salazar – 50th United States Secretary of the Interior, in the administration of President Barack Obama from 2009 to 2013. He is a descendant of Spanish settlers in New Spain in 16th century. 
José de la Cruz Sánchez (1799–1878) – eleventh Alcalde of San Francisco in 1845.
Francisco Sanchez (1805–1862) was Commandante of the San Francisco Presidio and the eighth alcalde of San Francisco, California in 1843. He was brother of José de la Cruz Sánchez.
Erasmo Seguín (1782–1857) – prominent citizen and politician in San Antonio, Texas. He was of French and Spanish descent in San Antonio de Bexar (now San Antonio, Texas). 
Juan Seguín (1806–1890) – Texas senator, mayor, judge, and justice of the peace and a prominent participant in the Texas Revolution. He was son of Erasmo Seguín.
Éamon de Valera (1882–1975) – American born leader of Ireland's struggle for independence from Britain in the War of Independence and of the anti-Treaty opposition in the ensuing Irish Civil War (1922–1923). He was the founder of Fianna Fáil, head of government ( President of the Executive Council, later Taoiseach) and President of Ireland (1959–1973). He was son to an Irish mother and a Cuban father of Spanish descent. 
Mariano Guadalupe Vallejo (July 4, 1807 – January 18, 1890) – Californio military commander, politician, and rancher.
Juan Verde – political, business and social entrepreneur from the Canary Islands and adviser to President Obama and several Democratic political campaigns Agustín V. Zamorano (1798–1842) – printer, soldier, and provisional Mexican colonial Governor of Alta California. He was born in Florida, by which him obtained the American citizenship when the territory be joined to United States
Sheriff, police, Texas Ranger and lawyers
Eugene W. Biscailuz (1883–1969) – Sheriff of Los Angeles County. His mother was descended from old Spanish settlers of California.
Tony Bouza – 40-year veteran of municipal police, serving as Minneapolis police chief from 1980 to 1989. He was born in Spain 
Alex Ferrer – American television personality, lawyer, and retired judge who presides as the arbiter on Judge Alex.
Manuel T. Gonzaullas (July 4, 1891 – February 13, 1977) – Spanish born American Texas Rangers captain and a staff member of the Texas government.
Rafael Piñeiro – Spanish-born American who served as First Deputy Commissioner of the New York City Police Department (NYPD).
Manuel Real – judge of the U.S. District Court for the Central District of California. 
Tomas Avila Sanchez (1826–1882) – American soldier, sheriff and public official, was on the Los Angeles County, California, Board of Supervisors and was a member of the Los Angeles Common Council, the legislative branch of the city. He was descendant of Spanish settlers. Michael G. Santos – American prison consultant, author of several books about prison, a professor of criminal justice, and an advocate for criminal justice reform. Santos is the son of a Cuban immigrant father and a mother of Spanish descent. 
Journalists and Reporters
Anderson Cooper – TV news reporter. Of English, Scottish, Irish, Welsh, Spanish and Dutch descent.
Krystal Fernandez – American sports journalist.
Bill Gallo (1922–2011) – cartoonist and newspaper columnist for the New York Daily News. 
Steve Lopez – American journalist who has been a columnist for The Los Angeles Times since 2001. He is the son of Spanish and Italian immigrants.
Suzanne Malveaux – TV news reporter. She comes from a Creole family in Louisiana of French, Spanish and African origin. 
Craig Rivera – American television journalist, producer, and correspondent for Fox News Channel. His father was a Puerto Rican of Sephardic Jew descent.
Sebastian Junger – American journalist, most famous for the best-selling book The Perfect Storm: A True Story of Men Against the Sea (1997)
Geraldo Rivera – American lawyer, journalist, writer, reporter and talk show host. His father was of Puerto Rican Sephardic Jew ancestry. He is brother of Craig Rivera.   Rosana Ubanell – Spanish-born American naturalized news journalist and the first Spanish language novelist to ever be published by Penguin Books
Novelist, poets and cartoonists of comic books
Alberto Acereda – writer, professor of Spanish language and literature in USA and Spanish author of numerous articles on politics and op-eds in several European and American newspapers.
Mercedes de Acosta (1893–1968) – poet and playwright, also known for her lesbian affairs with Greta Garbo and Marlene Dietrich. 
Felipe Alfau (1902–1999) – Catalan novelist and poet.
Jaime de Angulo (1887–1950) – linguist, novelist, and ethnomusicologist in the western United States. He was born in Paris of Spanish parents.
Estelle Anna Lewis (1824–1880) – United States poet and dramatist. She was of English and Spanish descent.
Sergio Aragonés – cartoonist and Spanish writer known for his contributions to Mad Magazine and creator of the comic book ." Groo the Wanderer 
José Argüelles (1939–2011) – American New Age author and artist. His father was Spanish.
Ivan Argüelles – American poet and brother of Jose Argüelles.
Alexander Argüelles – American linguist and son of Ivan Argüelles.
Hilario Barrero – Spanish poet and teacher. 
Stephen Vincent Benét (July 22, 1898 – March 13, 1943) – American author, poet, short story writer, and novelist.
Manuel Gonzales (1913 – 1993), Spanish born-American Disney comics artist.
Jessica Hagedorn – Filipino-American playwright, writer, poet, storyteller, musician, and multimedia performance artist, to a Scots-Irish-French-Filipino mother and a Filipino-Spanish father.
Amber L. Hollibaugh – American writer, film-maker and political activist. She is the daughter of a Romany father of Spanish descent and an Irish mother. 
Andrew Jolivétte – American author and lecturer of Spanish partially descent.
Lorraine C. Ladish – American author of American and Spanish descent.
Odón Betanzos Palacios (1925–2007) – poet, novelist and Spanish literary critic. 
Carmen M. Pursifull – English-language free verse poet and former New York City Latin dance and Latin American music figure in the 1950s. She is of Puerto Rican and Spanish descent. 
Anaïs Nin – born Angela Anaïs Juana Antolina Rosa Edelmira Nin y Culmell, was an American author born to Spanish-Cuban parents in France, where she was also raised.
George Rabasa – American writer and author
Matthew Randazzo V – American true crime writer and historian. He is of Sicilian-American, Isleño, and Cajun descent. 
George Santayana (1863–1952) – Spanish born, philosopher, essayist, poet, and novelist.
Jose Yglesias (November 29, 1919 – November 7, 1995) – American novelist and journalist. Yglesias was born in the Ybor City section of Tampa, Florida, and was of Cuban and Spanish descent. His father was from Galicia. Rafael Yglesias (born May 12, 1954, New York) – American novelist and screenwriter. His parents were the novelists Jose Yglesias and Helen Yglesias.
Ranchers and Landowners
Emilio S. Allué – Spanish-born American prelate of the Roman Catholic Church.
Joseph Sadoc Alemany (July 3, 1814 – April 14, 1888) – Catalan American Roman Catholic archbishop and missionary. He was naturalized in the United States in 1840.
Eusebius J. Beltran – American prelate. His father was Spanish.
Francisco Mora y Borrell (1827–1905) – Catalan American Roman Catholic priest
Thaddeus Amat y Brusi (1810–1878) – Roman Catholic Catalan cleric who eventually became Bishop of Los Angeles, California.
Henriette DeLille (1813–1862) – founded the Catholic order of the Sisters of the Holy Family in New Orleans, which was composed of free women of color. Her mother was a Creole of color of French, Spanish and African ancestry and was born in New Orleans. 
Robert Fortune Sanchez (1934–2012) – Archbishop of the Roman Catholic Archdiocese of Santa Fe, New Mexico. Some of his ancestors were Spanish settlers in New Mexico.
Josu Iriondo – Spanish born American prelate of the Roman Catholic Church. He currently serves as an auxiliary bishop of the Archdiocese of New York.
Antonio José Martínez (1793–1867) – Nuevomexicano priest, educator, publisher, rancher, farmer, community leader, and politician.
Ricky Rodriguez (1975–2005) – former member of the Children of God (COG), now known as The Family International (TFI).
Alfredo Méndez-Gonzalez (1907–1995) – American Catholic bishop who served in Puerto Rico. He was of Spanish and Puerto Rican descent. 
José González Rubio (1804–1875) – Roman Catholic friar prominent in the early history of California.
Peter Morales – President of the Unitarian Universalist Association, elected in 2009. Morales is the first Latino president. He is of Mexican and Spanish descent.
David Arias Pérez – Spanish-born Recollect friar in the United States.
Peter Verdaguer y Prat (December 10, 1835 – October 26, 1911) – Catalan-born American prelate of the Roman Catholic Church. Francisco González Valer – Spanish-born American prelate of the Roman Catholic Church.
Scholars, Professors and academics
Gloria Anzaldúa (1942–2004) – scholar of Chicana cultural theory, feminist theory, and queer theory. She descendant of many of the prominent Basque and Spanish explorers and settlers to come to the Americas in the 16th and 17th centuries.
Ángel Cabrera – Spanish academic and sixth President of George Mason University.
Ernest Fenollosa (1853–1908) – American professor of philosophy and political economy at Tokyo Imperial University.
Jorge Ferrer – chair of the department of East-West Psychology at the California Institute of Integral Studies.
Karl Hess (1923–1994) – American speechwriter and author. He was of German and Spanish descent.
Juan José Linz (1926–2013) – Spanish sociologist and political scientist.
Andrew Jolivétte – American author and lecturer who is employed at San Francisco State University as an associate professor in American Indian Studies and an instructor in Ethnic Studies, Educational Leadership, and Race and Resistance Studies.
Xavier Sala-i-Martin (born June 17, 1962, Cabrera de Mar, Barcelona, Catalonia Spain) – Catalan-American professor of economics at Columbia University.
Carlos Fernández-Pello – Spanish-born faculty member of the University of California, Berkeley, Department of Mechanical Engineering. Juan Bautista Rael (1900–1993) – Nuevomexicano ethnographer, linguist, and folklorist who was a pioneer in the study of the Nuevomexicanos, his stories and his language, both from Northern New Mexico and Southern Colorado.
Scientists, inventors and engineers
Michael Lopez-Alegria – Spanish-American astronaut. Holds American record for most EVA hours (spacewalks or moonwalks). Born in Madrid. 
Luis F. Alvarez (1853–1937) – developed diagnosis for macular leprosy
Luis W. Alvarez (1911–1988) – Nobel Prize-winning physicist and key participant in the Manhattan Project
Walter Alvarez – geologist who first proposed the asteroid-impact theory to explain the extinction of the dinosaurs
Walter C. Alvarez (1884–1978) – American doctor of Spanish descent. He authored several dozen books on medicine, and wrote introductions and forewords for many others. Referred to as "America's Family Doctor" for his syndicated medical column in hundreds of newspapers.
Francisco J. Ayala – biologist and philosopher, recipient of the 2010 Templeton Prize; born in Madrid
Isador Coriat (1875–1943) – American psychiatrist and neurologist. He was one of the first American psychoanalysts. He was of Moroccan-Spanish descent on father's side and German on mother's side. 
Pedro Cuatrecasas – American biochemist and an Adjunct Professor of Pharmacology & Medicine at the University of California, San Diego
Frank J. Duarte – laser physicist and author
Valentin Fuster – Catalan American cardiologist
Rodolfo Llinás – Professor of Neuroscience and Chairman of the department of Physiology & Neuroscience at the NYU School of Medicine. Born in Bogotá ( Colombia), with Spanish grandfather
Miguel A. Sanchez – Spanish-born American board-certified pathologist who specializes in anatomic pathology, clinical pathology and cytopathology.
Severo Ochoa (1905–1993) – Nobel Prize-winning biochemist who worked on the synthesis of RNA Ramón Verea (1833–1899) – Spanish journalist, engineer and writer. Inventor of a calculator with an internal multiplication table
Helene Hagan – Moroccan born American anthropologist and Amazigh activist. She is of Berber and Catalan descent.
Yasmin Aga Khan – philanthropist with Spanish blood from her mother, Rita Hayworth.
Juan Bautista Mariano Picornell y Gomila (1759–1825) – Spanish-born revolutionary.
Concepción Picciotto (1936–2016) – also known as Conchita or Connie, Spanish-born American that has lived in Lafayette Square, Washington, D.C. on the 1600 block of Pennsylvania Avenue, in a peace camp across from the White House, since August 1, 1981, in protest of nuclear arms
Alberto Rivera (1935–1997) – Canarian-born American anti-Catholic religious activist who was the source of many of fundamentalist Christian author Jack Chick's conspiracy theories about The Vatican.
Tony Serra – American civil rights lawyer, activist and tax resister from San Francisco. Andrea Heinemann Simon (1909–1994) – community leader and the mother of award-winning singer, Carly Simon. She is of Spanish-Swiss descent.
Aida de Acosta (1884–1962) – first woman to fly a plane solo motor.
Rodney Alcala – American convicted rapist and serial killer.
José Andrés - Spanish born-American naturalized chef.
Alonzo Morphy (1798–1856) – American lawyer serving as Attorney General of Louisiana (1828–1830), and a Justice of the Louisiana Supreme Court (1839–1846). He was of Spanish, Portuguese and Irish descent.
Concepción Argüello (1791–1857) – Alta Californian noted for her romance with Nikolai Rezanov, a Russian promoter of the colonization of Alaska and California. She was the daughter of José Darío Argüello, the Spanish governor of Alta California and Presidio Commandante.
John Henry Carpenter (1928–1998) – most widely known as the friend and accused murderer of actor Bob Crane in 1978. He was of Native American and Spanish heritage. 
Raymond Fernandez (1914–1951) – and his common-law wife Martha Beck became known as . The Lonely Hearts Killers 
Manuel A. Gonzalez (1832–1902) – 19th-century Spanish steamship captain and was one of the first permanent settlers of Fort Myers, Florida. He became a naturalized U.S. Citizen in May 1859, in Key West, Florida. 
Perez Hilton – American blogger and television personality.
Rita de Acosta Lydig (1875–1929) – socialite. She was considered "the most picturesque woman in America".
Paul Charles Morphy (1837–1884) – American chess player. 
Tony Pastor (May 28, 1837 – August 26, 1908) – American impresario. His father was a Spanish immigrant.   
Ignacio Peralta (1791–1874) – Spanish settler in California and son of Spanish soldier Luís María Peralta.
Kika Perez, aka Ilva Margarita Perez, is a Colombian American Actress/TV host of Spanish descent.
Augusto Perez – retired Spanish-born American wheelchair curler.
Manuel Torres (1762–1822) – Spanish born – American publicist and diplomat. He was the first ambassador of Colombia between June 19, 1822 and July 15, 1822 JWoww – American television personality, of Spanish-Irish descent. 
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