In 2011 she married Henrik Palmgren, the Swedish host of web media company Red Ice. According to the Southern Poverty Law Center, Red Ice started in 2003 covering the paranormal and conspiracy theories before shifting to white nationalism and antisemitism. Lokteff and Palmgren have been jointly cited as an influential introduction to white nationalism by members of the far right. Red Ice shifted around 2014 in response to what the couple perceived as "anti-white sentiment" coinciding with the Black Lives Matter movement.
Following the election of Donald Trump in 2016, Lokteff has attempted to increase the number of white women involved in the predominately male-dominated alt-right movement, advocating for them to play a supporting role to men. Lokteff opposes feminism, claiming that it has made life more difficult for men and that feminism's goals of equality have already been achieved. She has also criticized some of the women who have accused Harvey Weinstein of sexual assault.New York magazine describes her as a "looks-obsessed eugenicist", quoting her as saying "The alt-right is a very attractive, very sexy bunch ... Matches are being made left and right of beautiful, intelligent couples. It's a eugenic process."
She has been frequently trolled and threatened by members of the alt-right.
In 2018, Lokteff was a guest on the podcast of a Florida schoolteacher who used the pseudonym Tiana Dalichov. She used the podcast to encourage white nationalists to become schoolteachers to influence children.
In October 2019, Red Ice TV's YouTube channel was banned by YouTube for hate speech violations. The Channel had about 330,000 subscribers. Lokteff and Red Ice promoted a backup channel in an attempt to circumvent the ban. A week later, the backup channel was also removed by YouTube.