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|District of Sindh, Pakistan|
|District headquarters||Khairpur City|
|• Total||15,910 km2 (6,140 sq mi)|
|Elevation||61 m (200 ft)|
|• Density||150/km2 (390/sq mi)|
|Time zone||UTC+5 (PST)|
|Number of Tehsils||8|
|Number of Union Councils||89|
Khairpur District is a district in the Pakistani province of Sindh in Sukkur Division. At the 2017 census, it was the fifth most populated district in the province after four districts of Karachi city, with 2.4 million inhabitants. The headquarters of the district is the city of Khairpur. The district is further divided into eight sub-districts:Khairpur Taluka, Mirwah Taluka, Kot Diji Taluka, Kingri Taluka, Sobho Dero Taluka, Gambat Taluka, Faiz Ganj Taluka and Nara Taluka.
Khairpur district is located between middle and northern Sindh. It is bounded on the north by Shikarpur District and Sukkur District, on the east by India, on the south by Sanghar District and Nawabshah District, and on the west by Larkana District, Naushahro Feroze District and Indus River. The revised area of the district is 15,910 km².
According to the 2017 Census of Pakistan, the district had a population of 2.4 million, of which 32.3% was urban. Following are the demographic indicators of the district: