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KCNN4

KCNN4
Identifiers
AliasesKCNN4, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4, IK, DHS2, potassium calcium-activated channel subfamily N member 4
External IDsOMIM: 602754 MGI: 1277957 HomoloGene: 1696 GeneCards: KCNN4
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KCNN4
Genomic location for KCNN4
Band19q13.31Start43,766,533 bp[1]
End43,781,257 bp[1]
RNA expression pattern
PBB GE KCNN4 204401 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002250

NM_001163510
NM_008433

RefSeq (protein)

NP_002241

NP_001156982
NP_032459

Location (UCSC)Chr 19: 43.77 – 43.78 MbChr 7: 24.37 – 24.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[5]

Function

The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[5]

History

The channel activity was first described in 1958 by György Gárdos in human erythrocytes.[6] The channels is also named Gardos channel because of its discoverer.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104783 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054342 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4".
  6. ^ Gardos G (1958). "The function of calcium in the potassium permeability of human erythrocytes". Biochim. Biophys. Acta. 30 (3): 653–4. doi:10.1016/0006-3002(58)90124-0. PMID 13618284.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.