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KCNMB4

KCNMB4
Identifiers
AliasesKCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
External IDsOMIM: 605223 MGI: 1913272 HomoloGene: 8721 GeneCards: KCNMB4
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for KCNMB4
Genomic location for KCNMB4
Band12q15Start70,366,290 bp[1]
End70,434,292 bp[1]
RNA expression pattern
PBB GE KCNMB4 219287 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014505

NM_021452

RefSeq (protein)

NP_055320

NP_067427

Location (UCSC)Chr 12: 70.37 – 70.43 MbChr 10: 116.42 – 116.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.[5][6][7]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135643 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054934 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW (Apr 2000). "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4". J Biol Chem. 275 (9): 6453–61. doi:10.1074/jbc.275.9.6453. PMID 10692449.
  6. ^ Behrens R, Nolting A, Reimann F, Schwarz M, Waldschutz R, Pongs O (Jul 2000). "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family". FEBS Lett. 474 (1): 99–106. doi:10.1016/S0014-5793(00)01584-2. PMID 10828459.
  7. ^ a b "Entrez Gene: KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.