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AliasesKCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDsOMIM: 603939 MGI: 1891291 HomoloGene: 31266 GeneCards: KCNK6
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KCNK6
Genomic location for KCNK6
Band19q13.2Start38,319,845 bp[1]
End38,332,076 bp[1]
RNA expression pattern
PBB GE KCNK6 gnf1h00063 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 38.32 – 38.33 MbChr 7: 29.22 – 29.23 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.[5][6][7][8]

This gene encodes K2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.[8]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099337 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046410 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682.
  6. ^ Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428.
  7. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  8. ^ a b "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.