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KCNJ8

KCNJ8
Identifiers
AliasesKCNJ8, KIR6.1, uKATP-1, potassium voltage-gated channel subfamily J member 8, potassium inwardly rectifying channel subfamily J member 8
External IDsOMIM: 600935 MGI: 1100508 HomoloGene: 3654 GeneCards: KCNJ8
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for KCNJ8
Genomic location for KCNJ8
Band12p12.1Start21,764,955 bp[1]
End21,775,600 bp[1]
RNA expression pattern
PBB GE KCNJ8 205303 at fs.png

PBB GE KCNJ8 205304 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004982

NM_008428
NM_001330363
NM_001330366

RefSeq (protein)

NP_004973

NP_001317292
NP_001317295
NP_032454

Location (UCSC)Chr 12: 21.76 – 21.78 MbChr 6: 142.56 – 142.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein.[5] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121361 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030247 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.