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KCNJ3

KCNJ3
Protein KCNJ3 PDB 1n9p.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCNJ3, GIRK1, KGA, KIR3.1, potassium voltage-gated channel subfamily J member 3, potassium inwardly rectifying channel subfamily J member 3
External IDsOMIM: 601534 MGI: 104742 HomoloGene: 1687 GeneCards: KCNJ3
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for KCNJ3
Genomic location for KCNJ3
Band2q24.1Start154,697,855 bp[1]
End154,858,354 bp[1]
RNA expression pattern
PBB GE KCNJ3 207141 s at fs.png

PBB GE KCNJ3 207142 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002239
NM_001260508
NM_001260509
NM_001260510

NM_008426
NM_001304810
NM_001355118

RefSeq (protein)

NP_001247437
NP_001247438
NP_001247439
NP_002230

NP_001291739
NP_032452
NP_001342047

Location (UCSC)Chr 2: 154.7 – 154.86 MbChr 2: 55.44 – 55.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 3, also known as KCNJ3 or Kir3.1, is a human gene.[5]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.[5]

Interactions

KCNJ3 has been shown to interact with KCNJ5.[6][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162989 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026824 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3".
  6. ^ Huang, C L; Jan Y N; Jan L Y (Apr 1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Lett. 405 (3): 291–8. doi:10.1016/S0014-5793(97)00197-X. ISSN 0014-5793. PMID 9108307.
  7. ^ He, Cheng; Yan Xixin; Zhang Hailin; Mirshahi Tooraj; Jin Taihao; Huang Aijun; Logothetis Diomedes E (Feb 2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". J. Biol. Chem. 277 (8): 6088–96. doi:10.1074/jbc.M104851200. ISSN 0021-9258. PMID 11741896.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.