|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||312.489 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
JWH-133, alongside WIN 55,212-2 and HU-210, is responsible for preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through agonist action at cannabinoid receptors, which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.
The substance commonly referred to as "JWH-133" is not a scheduled substance in the U.S, except in Alabama. Low abuse potential makes it less likely for regulation relative to its sister drugs such as JWH-018, as JWH-133 is selective for the non-psychoactive CB2 receptor and thus lacks significant psychoactive effects.