|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||371.480 g·mol−1|
|3D model (JSmol)|
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype approximately 10x the affinity at CB2. It was discovered by and named after John W. Huffman.
JWH-081 may be neurotoxic to animals when administered in high doses.
As of October 2015, JWH-081 is a controlled substance in China.
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