This page uses content from Wikipedia and is licensed under CC BY-SA.

Ileal sodium/bile acid cotransporter

SLC10A2
Identifiers
AliasesSLC10A2, ASBT, IBAT, ISBT, NTCP2, PBAM, solute carrier family 10 member 2
External IDsOMIM: 601295 MGI: 1201406 HomoloGene: 390 GeneCards: SLC10A2
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for SLC10A2
Genomic location for SLC10A2
Band13q33.1Start103,043,998 bp[1]
End103,066,417 bp[1]
RNA expression pattern
PBB GE SLC10A2 207095 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000452

NM_011388

RefSeq (protein)

NP_000443

NP_035518

Location (UCSC)Chr 13: 103.04 – 103.07 MbChr 8: 5.08 – 5.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ileal sodium/bile acid cotransporter, also known as apical sodium–bile acid transporter (ASBT) and ileal bile acid transporter (IBAT), is a bile acid:sodium symporter protein that in humans is encoded by the SLC10A2 gene.[5][6]

ASBT/IBAT is most highly expressed in the ileum, where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.[7]

As a drug target

Several medications to inhibit IBAT are under development. They include elobixibat, under development for the treatment of constipation and irritable bowel syndrome,[8] and volixibat, under development for the treatment of nonalcoholic steatohepatitis.[9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125255 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023073 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wong MH, Rao PN, Pettenati MJ, Dawson PA (May 1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33". Genomics. 33 (3): 538–40. doi:10.1006/geno.1996.0233. PMID 8661017.
  6. ^ "Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2".
  7. ^ Dawson PA (2011). "Role of the intestinal bile acid transporters in bile acid and drug disposition". Handbook of Experimental Pharmacology (201): 169–203. doi:10.1007/978-3-642-14541-4_4. PMC 3249407. PMID 21103970.
  8. ^ Acosta A, Camilleri M (July 2014). "Elobixibat and its potential role in chronic idiopathic constipation". Therapeutic Advances in Gastroenterology. 7 (4): 167–75. doi:10.1177/1756283X14528269. PMC 4107709. PMID 25057297.
  9. ^ Chitnis D (2016-08-03), "FDA grants fast track status to volixibat", Internal Medicine News Digital Network, retrieved 2016-08-14.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.