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ITPR3

ITPR3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITPR3, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
External IDsOMIM: 147267 MGI: 96624 HomoloGene: 1675 GeneCards: ITPR3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ITPR3
Genomic location for ITPR3
Band6p21.31Start33,620,365 bp[1]
End33,696,574 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002224

NM_080553

RefSeq (protein)

NP_002215

NP_542120

Location (UCSC)Chr 6: 33.62 – 33.7 MbChr 17: 27.06 – 27.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.[5] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.[6]

Function

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000096433 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042644 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: inositol 1".
  6. ^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels. 2 (1): 9–22. PMID 8081734.
  7. ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655. PMID 20696704.

Further reading

External links