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Hyper-IgM syndrome type 3

Hyper-IgM syndrome type 3
IgM scheme.svg
Immunoglobulin M

Hyper-IgM syndrome type 3 is a form of hyper IgM syndrome characterized by mutations of the CD40 gene.[1] In this type, Immature B cells cannot receive signal 2 from helper T cells which is necessary to mature into mature B cells.


  1. ^ "OMIM Entry- # 606843 - IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 3; HIGM3". Retrieved 2018-02-23.

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External resources