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Homatropine methylbromide

Homatropine methylbromide
Methylhomatropine bromide.svg
Clinical data
SynonymsMethylhomatropine bromide
ATC code
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.001.168 Edit this at Wikidata
Chemical and physical data
Molar mass370.287 g·mol−1
3D model (JSmol)

Homatropine methylbromide (INN; also known as methylhomatropine bromide) is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal cramps, without producing the adverse effects of less specific anticholinergics.[1] It is used, in addition to papaverine, as a component of mild drugs that help "flush" the bile.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount of homatropine methylbromide to discourage intentional overdose.[2]


See also


  1. ^ "Paratropina (Homatropine Methylbromide)".
  2. ^ "Hydromet (Hydrocodone Bitartrate and Homatropine Methylbromide)". DailyMed. NIH.