Hodgkinsine is a trimer composed of three pyrrolidinoindoline subunits, with the monomer closely resembling another alkaloid eseroline which has similar bioactivity. Due to its complex structure and multiple chiral centres, hodgkinsine has many stereoisomers and significant research has been undertaken to elucidate the structure-activity relationships of the various isomers and synthetic derivatives structurally derived from hodgkinsine.
^Verotta L, Orsini F, Sbacchi M, Scheildler MA, Amador TA, Elisabetsky E (July 2002). "Synthesis and antinociceptive activity of chimonanthines and pyrrolidinoindoline-type alkaloids". Bioorganic & Medicinal Chemistry. 10 (7): 2133–42. doi:10.1016/s0968-0896(02)00078-0. PMID11983509.
^Kodanko JJ, Overman LE (June 2003). "Enantioselective total syntheses of the cyclotryptamine alkaloids hodgkinsine and hodgkinsine B". Angewandte Chemie. 42 (22): 2528–31. doi:10.1002/anie.200351261. PMID12800178.
^Kodanko JJ, Hiebert S, Peterson EA, Sung L, Overman LE, de Moura Linck V, et al. (October 2007). "Synthesis of all low-energy stereoisomers of the tris(pyrrolidinoindoline) alkaloid hodgkinsine and preliminary assessment of their antinociceptive activity". The Journal of Organic Chemistry. 72 (21): 7909–14. doi:10.1021/jo7013643. PMID17887704.