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Haloprogesterone

Haloprogesterone
Haloprogesterone.svg
Clinical data
Trade namesProhalone
SynonymsAloprogesterone; 6α-Fluoro-17α-bromoprogesterone; 6α-Fluoro-17α-bromopregn-4-ene-3,20-dione
Routes of
administration
By mouth
Drug classProgestin; Progestogen
ATC code
  • None
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC21H28BrFO2
Molar mass411.355 g/mol
3D model (JSmol)

Haloprogesterone, sold under the brand name Prohalone, is a progestin medication which was previously marketed by Ayerst but is now no longer available.[1][2][3]

Chemistry

Haloprogesterone, also known as 6α-fluoro-17α-bromoprogesterone or as 6α-fluoro-17α-bromopregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a halogenated derivative of progesterone.[1] It is specifically a derivative of 17α-bromoprogesterone and is similar structurally to medrogestone (6-dehydro-6,17α-dimethylprogesterone), medroxyprogesterone acetate (6α-methyl-17α-acetoxyprogesterone), and various other progestins derived from progesterone.[1]

Synthesis

Chemical syntheses of haloprogesterone have been published.[4]

History

Haloprogesterone was synthesized in 1960 and was introduced for medical use by 1961.[1][5][6]

Society and culture

Generic names

Haloprogesterone is the generic name of the drug and its INN and USAN.[1][3]

Brand names

Haloprogesterone was marketed under the brand name Prohalone.[1]

References

  1. ^ a b c d e f J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 620–. ISBN 978-1-4757-2085-3.
  2. ^ American Pharmaceutical Association (1976). APhA drug names: an index of drug names. American Pharmaceutical Association.
  3. ^ a b United States Adopted Names (USAN). United States Pharmacopeial Convention. 1968. p. 715.
  4. ^ Die Gestagene. Springer-Verlag. 27 November 2013. pp. 9–10. ISBN 978-3-642-99941-3.
  5. ^ Official Gazette of the United States Patent Office. The Office. 1961. p. 74.
  6. ^ The Journal of New Drugs. 1962. p. 127.