Glycopyrronium bromide Clinical data Trade names Robinul, Cuvposa, Seebri, Qbrexza, others License data
AU: B2 US: B (No risk in non-human studies) ATC code Legal status Legal status
3-[2-Cyclopentyl(hydroxy)phenylacetoxy]-1,1-dimethylpyrrolidinium bromide CAS Number PubChem CID ChemSpider UNII KEGG CompTox Dashboard ( EPA) ECHA InfoCard 100.008.990 Chemical and physical data Formula C 19 H 28 Br N O 3 Molar mass 398.335 g/mol g·mol −1 3D model ( JSmol)
Glycopyrronium Clinical data AHFS/ Drugs.com Monograph MedlinePlus a602014 Pregnancy category
US: B (No risk in non-human studies) Routes of administration By mouth, intravenous, inhalation, topical ATC code Legal status Legal status
Pharmacokinetic data Elimination half-life 0.6–1.2 hours Excretion 85% renal, unknown amount in the bile Identifiers
3-(2-Cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEMBL CompTox Dashboard ( EPA) ECHA InfoCard 100.008.990 Chemical and physical data Formula C 19 H 28 N O 3 + Molar mass 318.431 g/mol g·mol −1 3D model ( JSmol)
(what is this?) (verify) Glycopyrronium bromide is a medication of the muscarinic anticholinergic group. It does not cross the blood–brain barrier and consequently has no to few central effects. It is available in by mouth, intravenous, topical, and inhalated forms. It is a synthetic quaternary ammonium.
It was developed by Sosei and licensed to
Novartis in 2005. The cation, which is the active moiety, is called glycopyrronium ( INN) or  glycopyrrolate ( USAN).
In June 2018, glycopyrronium was approved by the FDA to treat excessive underarm sweating, becoming the first drug developed specifically to reduce excessive sweating.
anesthesia, glycopyrronium injection can be used as a before surgery in order to reduce salivary, tracheobronchial, and pharyngeal secretions, as well as decreasing the acidity of gastric secretion. It is also used in conjunction with neostigmine, a neuromuscular blocking reversal agent, to prevent neostigmine's muscarinic effects such as bradycardia.
It is also used to reduce excessive saliva (
sialorrhea),   and  Ménière's disease.
acid secretion in the stomach and so may be used for treating stomach ulcers, in combination with other medications.
It has been used topically and orally to treat
hyperhidrosis, in particular, gustatory hyperhidrosis. 
In inhalable form it is used to treat
chronic obstructive pulmonary disease (COPD). Doses for inhalation are much lower than oral ones, so that swallowing a dose will not have an effect. 
Since glycopyrronium reduces the body's sweating ability, it can even cause
hyperthermia and heat stroke in hot environments. Dry mouth, difficulty urinating, headaches, diarrhea and constipation are also observed side effects of the medication. The medication also induces drowsiness or blurred vision, an effect exacerbated by the consumption of alcohol.
Mechanism of action
muscarinic receptors, thus inhibiting  cholinergic transmission.
Glycopyrronium bromide affects the gastrointestinal tracts, liver and kidney but has a very limited effect on the brain and the
central nervous system. In horse studies, after a single intravenous infusion, the observed tendencies of glycopyrronium followed a tri-exponential equation, by rapid disappearance from the blood followed by a prolonged terminal phase. Excretion was mainly in urine and in the form of an unchanged drug. Glycopyrronium has a relatively slow diffusion rate, and in a standard comparison to atropine, is more resistant to penetration through the blood-brain barrier and placenta.
It has been studied in
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