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GSK-789,472

GSK-789,472
GSK-789,472.svg
Clinical data
ATC code
  • none
Identifiers
ChemSpider
Chemical and physical data
FormulaC15H21N3O
Molar mass259.168 g/mol g·mol−1
3D model (JSmol)
  (verify)

GSK-789,472 is a drug which acts as both a potent and selective partial agonist at the dopamine receptor D2, as well as an antagonist at the related D3 subtype, but with good selectivity over D4 and other unrelated receptors.[1]

References

  1. ^ Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP (March 2010). "The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure". Bioorganic & Medicinal Chemistry Letters. 20 (6): 2013–6. doi:10.1016/j.bmcl.2010.01.090. PMID 20153647.