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AliasesGPR182, 7TMR, ADMR, AM-R, AMR, G10D, gamrh, hrhAMR, G protein-coupled receptor 182, L1-R
External IDsOMIM: 605307 MGI: 109545 HomoloGene: 5255 GeneCards: GPR182
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for GPR182
Genomic location for GPR182
Band12q13.3Start56,994,492 bp[1]
End56,998,447 bp[1]
RNA expression pattern
PBB GE ADMR 214506 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 12: 56.99 – 57 MbChr 10: 127.75 – 127.75 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.[5]

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.[6] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).[7]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166856 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058396 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–4908. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
  6. ^ Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID 9367907.
  7. ^ Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID 9535752.
  8. ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–339. doi:10.1038/30666. PMID 9620797.

Further reading

External links

  • "GPR182". IUPHAR GPCR Database. International Union of Pharmacology (IUPHAR). 2007-12-04. Retrieved 2008-07-03.