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GPR12

GPR12
Identifiers
AliasesGPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDsOMIM: 600752 MGI: 101909 HomoloGene: 3868 GeneCards: GPR12
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for GPR12
Genomic location for GPR12
Band13q12.13Start26,755,200 bp[1]
End26,760,786 bp[1]
RNA expression pattern
PBB GE GPR12 214558 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005288

RefSeq (protein)

NP_005279

Location (UCSC)Chr 13: 26.76 – 26.76 MbChr 5: 146.58 – 146.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[5][6][7]

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132975 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041468 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (Jan 1994). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Lett. 336 (2): 317–322. doi:10.1016/0014-5793(93)80828-I. PMID 8262253.
  6. ^ Song ZH, Modi W, Bonner TI (Feb 1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
  7. ^ "Entrez Gene: GPR12 G protein-coupled receptor 12".
  8. ^ Bjursell, Mikael; Gerdin, Anna-Karin; Jönsson, Marie; Surve, Vikas V.; Svensson, Lennart; Huang, Xu-Feng; Törnell, Jan; Bohlooly-Y, Mohammad (2006-09-22). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–366. doi:10.1016/j.bbrc.2006.07.090. ISSN 0006-291X. PMID 16887097.

Further reading