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AliasesGJA4, CX37, gap junction protein alpha 4
External IDsOMIM: 121012 MGI: 95715 HomoloGene: 1556 GeneCards: GJA4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GJA4
Genomic location for GJA4
Band1p34.3Start34,792,999 bp[1]
End34,795,747 bp[1]
RNA expression pattern
PBB GE GJA4 204904 at fs.png

PBB GE GJA4 40687 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 34.79 – 34.8 MbChr 4: 127.31 – 127.31 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Gap junction alpha-4 protein, also known as Connexin-37 or Cx37, is a protein that in humans is encoded by the GJA4 gene.[5][6][7] This protein, like other Connexin proteins, forms connections between cells known as gap junctions. Connexin 37 can be found in many tissues including the ovary[8], heart[9], and kidney[10].


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187513 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050234 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Richard G, Smith LE, Bailey RA, Itin P, Hohl D, Epstein EH, DiGiovanna JJ, Compton JG, Bale SJ (December 1998). "Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis". Nature Genetics. 20 (4): 366–9. doi:10.1038/3840. PMID 9843209.
  6. ^ Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC (March 1993). "Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein". The Journal of Clinical Investigation. 91 (3): 997–1004. doi:10.1172/JCI116321. PMC 288052. PMID 7680674.
  7. ^ "Entrez Gene: GJA4 gap junction protein, alpha 4, 37kDa".
  8. ^ Winterhager E, Kidder GM (May 2015). Gap junction connexins in female reproductive organs: implications for women's reproductive health. Human Reproduction Update. 21. pp. 340–52. doi:10.1093/humupd/dmv007. PMID 25667189.
  9. ^ Duffy HS, Fort AG, Spray DC (2006). "Cardiac connexins: genes to nexus". Cardiovascular Gap Junctions. Advances in Cardiology. 42. pp. 1–17. doi:10.1159/000092550. ISBN 978-3-8055-8077-9. PMID 16646581.
  10. ^ Hanner F, Sorensen CM, Holstein-Rathlou NH, Peti-Peterdi J (May 2010). "Connexins and the kidney". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 298 (5): R1143–55. doi:10.1152/ajpregu.00808.2009. PMC 2867516. PMID 20164205.

Further reading