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IUPAC name
(R/S)-2,4′-Dichloro-α-(pyrimidin-5-yl)benzhydryl alcohol
Other names
3D model (JSmol)
ECHA InfoCard 100.056.432
Molar mass 331.20 g·mol−1
Appearance Colorless powder with aromatic odor
Melting point 117 to 119 °C (243 to 246 °F; 390 to 392 K)[1]
Boiling point 240 °C (464 °F; 513 K) (decomposition)[1]
13.7 mg/L at 25 °C
Solubility in other solvents Soluble in acetone, xylene and methanol[1]
Vapor pressure 65 μ Pa (25 °C)[1]
Lethal dose or concentration (LD, LC):
>2000 mg·kg−1 (oral, Rat)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Fenarimol, sold under the tradenames Bloc, Rimidin and Rubigan, is a fungicide which acts against rusts, blackspot and mildew fungi. It is used on ornamental plants, trees, lawns, tomatoes, peppers, eggplants, cucumbers and melons. It is mainly used to control powdery mildew. It works by inhibiting the fungus's biosynthesis of important steroid molecules (via blockade of the CYP51 enzyme).[2]


Fenarimol was developed by Eli Lilly & Company around 1971.[3]

As of early 2018, derivatives of this compound are being researched in an open source manner for possible treatment of eumycetoma.[4]


Fenarimol is made by the reaction of 2,4'-dichlorobenzophenone with an organolithium pyrimidine made via bromine-lithium exchange.[2]



  1. ^ a b c d e EU-Data.
  2. ^ a b Clayden J, Greeves N, Warren S (2005). Organic chemistry (Reprinted (with corrections) ed.). Oxford [u.a.]: Oxford Univ. Press. p. 216. ISBN 978-0-19-850346-0.
  3. ^ GB 1218623  "Substituted-5-pyrimidine compounds "
  4. ^ Reynolds, Todd B.; Lim, Wilson; Melse, Youri; Konings, Mickey; Phat Duong, Hung; Eadie, Kimberly; Laleu, Benoît; Perry, Benjamin; Todd, Matthew H.; Ioset, Jean-Robert; van de Sande, Wendy W. J. (2018). "Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma". PLOS Neglected Tropical Diseases. 12 (4): e0006437. doi:10.1371/journal.pntd.0006437. ISSN 1935-2735.

External links

  • Fenarimol in the Pesticide Properties DataBase (PPDB)