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Protein FZD8 PDB 1ijy.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesFZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDsOMIM: 606146 MGI: 108460 HomoloGene: 40606 GeneCards: FZD8
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for FZD8
Genomic location for FZD8
Band10p11.21Start35,638,249 bp[1]
End35,642,278 bp[1]
RNA expression pattern
PBB GE FZD8 216587 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 35.64 – 35.64 MbChr 18: 9.21 – 9.22 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[5][6]


This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[6]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177283 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036904 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.
  6. ^ a b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

Further reading

External links

  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Frizzled-8 (FZD8)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.