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FZD7

FZD7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFZD7, FzE3, frizzled class receptor 7
External IDsOMIM: 603410 MGI: 108570 HomoloGene: 20751 GeneCards: FZD7
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for FZD7
Genomic location for FZD7
Band2q33.1Start202,034,587 bp[1]
End202,038,445 bp[1]
RNA expression pattern
PBB GE FZD7 203706 s at fs.png

PBB GE FZD7 203705 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003507

NM_008057

RefSeq (protein)

NP_003498

NP_032083

Location (UCSC)Chr 2: 202.03 – 202.04 MbChr 1: 59.48 – 59.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[5][6][7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[7]

Interactions

FZD7 has been shown to interact with DLG4.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155760 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041075 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
  6. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
  7. ^ a b "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".
  8. ^ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. Netherlands. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.

Further reading

External links

  • "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.