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FZD2

FZD2
Identifiers
AliasesFZD2, Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2
External IDsOMIM: 600667 MGI: 1888513 HomoloGene: 20377 GeneCards: FZD2
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for FZD2
Genomic location for FZD2
Band17q21.31Start44,557,484 bp[1]
End44,561,262 bp[1]
RNA expression pattern
PBB GE FZD2 210220 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001466

NM_020510

RefSeq (protein)

NP_001457

NP_065256

Location (UCSC)Chr 17: 44.56 – 44.56 MbChr 11: 102.6 – 102.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.[5][6][7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180340 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050288 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics. 27 (2): 370–3. doi:10.1006/geno.1995.1060. PMID 7558010.
  6. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
  7. ^ a b "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)".

Further reading

External links

  • "Frizzled Receptors: FZD2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.