The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
^Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID10702276.
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Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT (Nov 1994). "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science. 266 (5186): 819–22. doi:10.1126/science.7973639. PMID7973639.
Wilson SE, Walker JW, Chwang EL, He YG (Jul 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science. 34 (8): 2544–61. PMID8392040.
Guo L, Degenstein L, Fuchs E (Jan 1996). "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development. 10 (2): 165–75. doi:10.1101/gad.10.2.165. PMID8566750.
Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (Jun 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID8663044.
Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK (Oct 1996). "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development. 122 (10): 3107–15. PMID8898224.
Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K (Oct 1998). "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology. 107 (10 Pt 1): 885–90. doi:10.1177/000348949810701013. PMID9794620.
Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID10702276.
1qqk: THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7 (KERATINOCYTE GROWTH FACTOR)