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FGF12

FGF12
Protein FGF12 PDB 1q1u.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFGF12, FGF12B, FHF1, fibroblast growth factor 12, EIEE47
External IDsOMIM: 601513 MGI: 109183 HomoloGene: 10874 GeneCards: FGF12
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for FGF12
Genomic location for FGF12
Band3q28-q29Start192,139,395 bp[1]
End192,767,764 bp[1]
RNA expression pattern
PBB GE FGF12 207501 s at fs.png

PBB GE FGF12 214589 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004113
NM_021032
NM_001377292
NM_001377293
NM_001377294

NM_001276419
NM_001276420
NM_010199
NM_183064
NM_001357064

RefSeq (protein)

NP_004104
NP_066360
NP_001364221
NP_001364222
NP_001364223

NP_001263348
NP_001263349
NP_034329
NP_898887
NP_001343993

Location (UCSC)Chr 3: 192.14 – 192.77 MbChr 16: 28.16 – 28.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.[5][6][7]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114279 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022523 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.
  6. ^ Liu Y, Chiu IM (Nov 1997). "Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization". Cytogenet Cell Genet. 78 (1): 48–9. doi:10.1159/000134625. PMID 9345906.
  7. ^ a b "Entrez Gene: FGF12 fibroblast growth factor 12".

Further reading