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F2RL2

F2RL2
Identifiers
AliasesF2RL2, PAR-3, PAR3, coagulation factor II thrombin receptor like 2
External IDsOMIM: 601919 MGI: 1298208 HomoloGene: 36151 GeneCards: F2RL2
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for F2RL2
Genomic location for F2RL2
Band5q13.3Start76,615,482 bp[1]
End76,623,413 bp[1]
RNA expression pattern
PBB GE F2RL2 206795 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004101
NM_001256566

NM_010170

RefSeq (protein)

NP_001243495
NP_004092

NP_034300

Location (UCSC)Chr 5: 76.62 – 76.62 MbChr 13: 95.7 – 95.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

Function

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164220 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021675 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.