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Chemical and physical data
Molar mass203.329 g·mol−1
3D model (JSmol)

Eticyclidine (PCE, CI-400) is a dissociative anesthetic drug with hallucinogenic effects. It is similar in effects to phencyclidine but is slightly more potent. PCE was developed by Parke-Davis in the 1970s and evaluated for anesthetic potential under the code name CI-400,[1] but research into PCE was not continued after the development of ketamine, a similar drug with more favourable properties.[2] PCE is slightly more potent than PCP and has similar effects,[medical citation needed] but its unpleasant taste and tendency to cause nausea made it less accepted by users.[citation needed] Due to its similarity in effects to PCP, PCE was placed into the Schedule 1 list of illegal drugs in the 1970s, although it was only briefly abused in the 1970s and 1980s and is now little known.

See also


  1. ^ Levy, Leonard; Cameron, D. Ewen; Aitken, R. Cairns B. (1960). "Observation on Two Psychotomimetic Drugs of Piperidine Derivation–Ci 395 (Sernyl) and Ci 400". American Journal of Psychiatry. 116 (9): 843–844. doi:10.1176/ajp.116.9.843.
  2. ^ Kalir, Asher; Edery, Habib; Pelah, Zvi; Balderman, D.; Porath, Gila (1969). "1-Phenylcycloalkylamine derivatives. II. Synthesis and pharmacological activity". Journal of Medicinal Chemistry. 12 (3): 473–477. doi:10.1021/jm00303a030.