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Chemical and physical data
Molar mass423.350 g·mol−1

Estrobin, also known as α,α-di(p-ethoxyphenyl)-β-phenylbromoethylene and commonly abbreviated as DBE, is a synthetic, nonsteroidal estrogen of the triphenylethylene group that was never marketed.[1][2] Chlorotrianisene, and subsequently clomifene and tamoxifen, were derived from it.[1][2] Estrobin, similarly to other triphenylethylenes, is very lipophilic and hence very long-lasting in its duration of action.[1][2] Similarly to chlorotrianisene, estrobin behaves a prodrug to a much more potent estrogen in the body.[2]

See also


  1. ^ a b c Virgil Craig Jordan (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 23–. ISBN 978-0-299-10480-1.
  2. ^ a b c d Welsh, Ashton L. (1954). "USE OF SYNTHETIC ESTROGENIC SUBSTANCE CHLOROTRIANISENE (TACE) IN TREATMENT OF ACNE". Archives of Dermatology. 69 (4): 418. doi:10.1001/archderm.1954.01540160020004. ISSN 0003-987X.