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Estradiol palmitate

Estradiol palmitate
Estradiol palmitate structure.svg
Clinical data
Trade namesEsmopal
Other namesEstradiol monopalmitate; Estradiol hexadecanoate; Estradiol 17β-hexadecanoate
Drug classEstrogen; Estrogen ester
CAS Number
PubChem CID
ECHA InfoCard100.024.819 Edit this at Wikidata
Chemical and physical data
Molar mass510.803 g·mol−1
3D model (JSmol)

Estradiol palmitate (brand name Esmopal), or estradiol monopalmitate, also known as estradiol 17β-hexadecanoate, is a naturally occurring[1] steroidal estrogen and an estrogen ester – specifically, the C17β palmitate ester of estradiol.[2] It occurs in the body as a very long-lasting metabolite and prohormone of estradiol.[1] The compound has no affinity for the estrogen receptor, requiring transformation into estradiol for its estrogenic activity.[3] In addition to its endogenous role, estradiol palmitate was formerly used as a fattening agent in chickens under the brand name Esmopal.[4][5][6][7][8]

See also


  1. ^ a b Hochberg RB, Pahuja SL, Larner JM, Zielinski JE (1990). "Estradiol-fatty acid esters. Endogenous long-lived estrogens". Ann. N. Y. Acad. Sci. 595: 74–92. doi:10.1111/j.1749-6632.1990.tb34284.x. PMID 2197972.
  2. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 898. ISBN 978-1-4757-2085-3.
  3. ^ Janocko, Laura; Larner, Janice M.; Hochberg, Richard B. (1984). "The Interaction of C-17 Esters of Estradiol with the Estrogen Receptor*". Endocrinology. 114 (4): 1180–1186. doi:10.1210/endo-114-4-1180. ISSN 0013-7227.
  4. ^ Gerrits, R. J. (1970). The Influence of Hormones on the Production of Meat. Sci Teacher.
  5. ^ Gardiner EE, Newberry RC, Hunt JR (1988). "Effect of estradiol-17 beta-monopalmitate on the incidence of sudden death syndrome in male broiler chickens". Poult. Sci. 67 (1): 156–7. doi:10.3382/ps.0670156. PMID 3375173.
  6. ^ Bassila, M. K.; Adams, R. L.; Pratt, D. E.; Stadelman, W. J. (1975). "Effects of Sex, Strain and Estrogens on Quality of Chicken Roasters". Poultry Science. 54 (3): 696–702. doi:10.3382/ps.0540696. ISSN 0032-5791.
  7. ^ Moran, E. T.; Etches, R. J. (1983). "Finishing Broiler Toms Using an Estradiol 17 Implant Together with a High Energy-Low Protein Final Feed". Poultry Science. 62 (6): 1010–1020. doi:10.3382/ps.0621010. ISSN 0032-5791.
  8. ^ Mickelberry, W. C. (1968). "Influence of Dietary Fats and Estradiol 17 Beta Monopalmitate Upon the Edible Meat Yield of Roaster Chickens". Poultry Science. 47 (4): 1254–1257. doi:10.3382/ps.0471254. ISSN 0032-5791.