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Esterified estrogens/methyltestosterone

Esterified estrogens /
Combination of
Esterified estrogensEstrogen
Clinical data
Trade namesCovaryx, Essian, Estratest, Menogen, Syntest
Routes of
By mouth
Drug classEstrogen; Androgen
ATC code

Esterified estrogens/methyltestosterone, sold under brand names such as Covaryx, Eemt, Essian, Estratest, Menogen, and Syntest, is a hormonal preparation that combines esterified estrogens with methyltestosterone in one tablet and is used in menopausal hormone therapy.[1]

Medical uses

Estratest is used to treat menopausal women who suffer from hot flashes, but do not get relief from estrogen-only therapy.

Available forms

Estratest is sold in tablet form, with either 1.25 mg estrogens/2.5 mg methyltestosterone or 0.625 mg estrogens/1.25 mg methyltestosterone available.


The product is a combination of esterified estrogens, an estrogen, and low-dose methyltestosterone, an androgen/anabolic steroid, in a single tablet.


Estratest was first marketed in the United States in 1965 by Reid-Provident Laboratories, which as 100% of Reid-Rowell, Inc. stock was acquired by the Belgian pharmaceutical company Solvay in 1986. There has been some controversy surrounding the drug in recent years as to its status with the U.S. Food and Drug Administration.

Solvay sponsored a clinical trial of Estratest in the United States to determine whether the product is superior to treatment with esterified estrogens tablets.

Estratest was supplied by Solvay. In March 2009 Solvay announced that, based on a variety of business factors, it would discontinue supplying Estratest and Estratest HS tablets, and would stop accepting orders for the product on March 31, 2009.

See also


External links