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Ephrin B2

EFNB2
Protein EFNB2 PDB 1iko.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEFNB2, EPLG5, HTKL, Htk-L, LERK5, ephrin B2
External IDsOMIM: 600527 MGI: 105097 HomoloGene: 3019 GeneCards: EFNB2
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for EFNB2
Genomic location for EFNB2
Band13q33.3Start106,489,745 bp[1]
End106,535,662 bp[1]
RNA expression pattern
PBB GE EFNB2 202669 s at fs.png

PBB GE EFNB2 202668 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004093
NM_001372056
NM_001372057
NM_001372058

NM_010111
NM_001368299

RefSeq (protein)

NP_004084
NP_001358985
NP_001358986
NP_001358987

NP_034241
NP_001355228

Location (UCSC)Chr 13: 106.49 – 106.54 MbChr 8: 8.62 – 8.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene.[5]

Function

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.[6]

Cancer

EFNB2 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[7] For this reason, EFNB2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[7]

Interactions

EFNB2 has been shown to interact with EPHA3[8][9] and EPHB1 in optic chiasm development.[10]

EFNB2 has also been shown to serve as a receptor for Hendra Virus and Nipah Virus, mediating entry into the cell during infection.[11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125266 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001300 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bonaldo MF, Yu MT, Jelenc P, Brown S, Su L, Lawton L, Deaven L, Efstratiadis A, Warburton D, Soares MB (Sep 1994). "Selection of cDNAs using chromosome-specific genomic clones: application to human chromosome 13". Human Molecular Genetics. 3 (9): 1663–73. doi:10.1093/hmg/3.9.1663. PMID 7833926.
  6. ^ "Entrez Gene: EFNB2 ephrin-B2".
  7. ^ a b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.
  8. ^ Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ (Nov 1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases". Molecular Immunology. 32 (16): 1197–205. doi:10.1016/0161-5890(95)00108-5. PMID 8559144.
  9. ^ Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF, Howlett GJ, Olsson JE, Vanden Bos T, Cerretti DP, Boyd AW (Jun 1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor". The Journal of Biological Chemistry. 272 (26): 16521–30. doi:10.1074/jbc.272.26.16521. PMID 9195962.
  10. ^ Williams SE, Mann F, Erskine L, Sakurai T, Wei S, Rossi DJ, Gale NW, Holt CE, Mason CA, Henkemeyer M (September 2003). "Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm". Neuron. 39 (6): 919–35. doi:10.1016/j.neuron.2003.08.017. PMID 12971893.
  11. ^ Bonaparte MI, Dimitrov AS, Bossart KN, Crameri G, Mungall BA, Bishop KA, Choudhry V, Dimitrov DS, Wang LF, Eaton BT, Broder CC (July 2005). "Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus". Proceedings of the National Academy of Sciences of the United States of America. 102 (30): 10652–7. doi:10.1073/pnas.0504887102. PMC 1169237. PMID 15998730.

Further reading