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Dimemebfe ( 5-MeO-BFE) is a recreational drug and  research chemical. It acts as an agonist for the 5-HT and 1A 5-HT family of 2 serotonin receptors. It is related in structure to the psychedelic tryptamine derivative 5-MeO-DMT, but with the indole nitrogen replaced by oxygen, making dimemebfe a benzofuran derivative. It is several times less potent as a serotonin agonist than 5-MeO-DMT and with relatively more activity at 5-HT 1A, but still shows strongest effects at the 5-HT 2 family of receptors.
Dimemebfe is a
Schedule I controlled substance in the US state of Alabama.
John F. Casale and Patrick A. Hays. "The Characterization of 2-(5-Methoxy-1-benzofuran-3-yl)-N,N-dimethylethanamine (5-MeO-BFE) and Differentiation from its N-Ethyl Analog" (PDF). Microgram Journal. 9 (1): 39–45.
Tomaszewski, Z.; Johnson, M. P.; Huang, X.; Nichols, D. E. (1992). "Benzofuran bioisosteres of hallucinogenic tryptamines". Journal of Medicinal Chemistry. 35 (11): 2061–2064. doi: 10.1021/jm00089a017. PMID 1534585.
"Alabama Senate Bill 333 - Controlled substances, Schedule I, additional synthetic controlled substances and analogue substances included in, trafficking in controlled substance analogues, requisite weight increased, Secs. 13A-12-231, 20-2-23 am'd". March 2014 . Retrieved . 28 September 2015