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Dienestrol diacetate

Dienestrol diacetate
Dienestrol diacetate.svg
Clinical data
Trade namesFaragynol, Gynocyrol
Drug classNonsteroidal estrogen; Estrogen ester
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC22H22O4
Molar mass350.414 g·mol−1
3D model (JSmol)

Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1] It is an ester of dienestrol.[1]

Oral potencies of estrogens

Estrogen Type Class ETD
(2–3 weeks)
EPD
(2–3 weeks)
MSD
(2–3 weeks)
MSD
(daily)
OID
(daily)
TSD
(daily)
Estradiol (non-micronized) Bioidentical Steroidal 30 mg ≥120–300 mg 120 mg 6 mg ? ?
Estradiol (micronized) Bioidentical Steroidal 6–12 mg 60–80 mg 14–42 mg 1–2 mg ? >8 mg
Estradiol valerate Bioidentical Steroidal 6–12 mg 60–80 mg 14–42 mg 1–2 mg ? >8 mg
Estradiol benzoate Bioidentical Steroidal ? 60–140 mg ? ? ? ?
Estriol Bioidentical Steroidal 20 mga 120–150 mgb 28–126 mg 1–6 mg ? ?
Estriol succinate Bioidentical Steroidal ? 140–150 mgb 28–126 mg 2–6 mg ? ?
Estrone sulfate Bioidentical Steroidal 12 mg 60 mg 42 mg 2 mg ? ?
Conjugated estrogens Natural Steroidal 5–12 mg 60–80 mg 8.4–25 mg 0.625–1.25 mg ? 7.5 mg
Ethinylestradiol Synthetic Steroidal 200 μg 1–2 mg 280 μg 20–40 μg 100 μg 100 μg
Mestranol Synthetic Steroidal 300 μg 1.5–3.0 mg 300–600 μg 25–30 μg ? ?
Quinestrol Synthetic Steroidal 300 μg 2–4 mg 500 μg 25–50 μg ? ?
Methylestradiol Synthetic Steroidal ? 2 mg ? ? ? ?
Diethylstilbestrol Synthetic Nonsteroidal 2.5 mg 20–30 mg 11 mg 0.5–2.0 mg ? 3 mg
Diethylstilbestrol dipropionate Synthetic Nonsteroidal ? 15–30 mg ? ? ? ?
Dienestrol Synthetic Nonsteroidal 5 mg 30–40 mg 42 mg 0.5–4.0 mg ? ?
Dienestrol diacetate Synthetic Nonsteroidal 3–5 mg 30–60 mg ? ? ? ?
Hexestrol Synthetic Nonsteroidal ? 70–110 mg ? ? ? ?
Hexestrol diacetate Synthetic Nonsteroidal ? 45 mg ? ? ? ?
Chlorotrianisene Synthetic Nonsteroidal ? >100 mg ? ? ? ?
Methallenestril Synthetic Nonsteroidal ? 400 mg ? ? ? ?
Footnotes: a = Very variable, often higher. b = In divided doses, 3x/day; irregular and atypical proliferation. Sources: See template.

Parenteral potencies and durations of nonsteroidal estrogens

Estrogen Form Major brand name(s) EPD (14 days) Duration
Diethylstilbestrol (DES) Oil solution ? 20 mg 3 mg ≈ 3 days
Diethylstilbestrol dipropionate Oil solution Cyren B 12.5–15 mg 2.5 mg ≈ 5 days
Aqueous suspension ? 5 mg ? mg = 21–28 days
Dimestrol (DES dimethyl ether) Oil solution Depot-Cyren, Depot-Oestromon, Retalon Retard 20–40 mg ?
Fosfestrol (DES diphosphate)a Aqueous solution Honvan ? <1 day
Dienestrol diacetate Aqueous suspension Farmacyrol-Kristallsuspension 50 mg ?
Hexestrol dipropionate Oil solution Hormoestrol, Retalon Oleosum 25 mg ?
Hexestrol diphosphatea Aqueous solution Cytostesin, Pharmestrin, Retalon Aquosum ? Very short
Note: All by intramuscular injection unless otherwise noted. Footnotes: a = By intravenous injection. Sources: See template.

See also

References

  1. ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 390. ISBN 978-1-4757-2085-3.