This page uses content from Wikipedia and is licensed under CC BY-SA.

Dicentrine

Dicentrine
Dicentrine.png
Names
IUPAC name
(12S)-16,17-Dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14,16,18-hexaene
Other names
(S)-(+)-Dicentrine
Identifiers
3D model (JSmol)
ChemSpider
Properties
C20H21NO4
Molar mass 339.391 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Dicentrine is an aporphinic alkaloid found in several plant species, mainly from family Lauraceae, including Lindera megaphylla.[1] Dicentrine shows antinociceptive activity in a mouse model of pain.[2] It probably acts via a TRPA1-dependent mechanism.

References

  1. ^ Huang, Ray-Ling; Chen, Chien-Chih; Huang, Yu-Lin; Ou, Jun-Chih; Hu, Cheng-Po; Chen, Chieh-Fu; Chang, Chungming (1998). "Anti-Tumor Effects ofd-Dicentrine from the Root of Lindera megaphylla". Planta Medica. 64 (3): 212–215. doi:10.1055/s-2006-957411. PMID 9581516.
  2. ^ Montrucchio, Deise Prehs; Córdova, Marina Machado; Santos, Adair Roberto Soares (2013-07-04). "Plant Derived Aporphinic Alkaloid S-(+)-Dicentrine Induces Antinociceptive Effect in Both Acute and Chronic Inflammatory Pain Models: Evidence for a Role of TRPA1 Channels". PLOS ONE. 8 (7): e67730. Bibcode:2013PLoSO...867730M. doi:10.1371/journal.pone.0067730. ISSN 1932-6203. PMC 3701576. PMID 23861794.