Dexanabinol Clinical data ATC code Identifiers
(6a S,10a S)-9-(Hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[ c]chromen-1-ol CAS Number PubChem CID ChemSpider UNII CompTox Dashboard ( EPA) ECHA InfoCard 100.201.022 Chemical and physical data Formula C 25 H 38 O 3 Molar mass g·mol 386.576 −1 3D model ( JSmol)
(what is this?) (verify)
Dexanabinol ( HU-211 or ETS2101 ) is a  synthetic cannabinoid derivative in development by e-Therapeutics plc. It is the "unnatural" enantiomer of the potent cannabinoid agonist HU-210. Unlike other  cannabinoid derivatives, HU-211 does not act as a cannabinoid receptor agonist, but instead has NMDA antagonist effects. It therefore does not produce cannabis-like effects, but is  anticonvulsant and neuroprotective, and is widely used in scientific research as well as currently being studied for applications such as treating head injury, stroke, or cancer.   It was shown to be safe in  clinical trials and is currently undergoing  Phase I trials for the treatment of brain cancer and advanced solid tumors. 
Dexanabinol has been studied in IV administration and oral dosing.
e-Therapeutics is evaluating the compound in clinical trials for brain and solid cancers.  Phase II studies are planned based on the results of the current trials.
A phase 1b study for hepatocellular carcinoma and pancreatic cancer was started in 2015.
HU-211 is not listed in the schedules set out by the
United Nations' Single Convention on Narcotic Drugs from 1961 nor their Convention on Psychotropic Substances from 1971, so the signatory countries to these international drug control treaties are not required by said treaties to control HU-211.
HU-211 is not listed in the
list of scheduled controlled substances in the USA. It is therefore not  scheduled at the federal level in the United States, but it is possible that HU-211 could legally be considered an analog of Delta-8-THC (one of the THC isomers which is in Schedule I under the designation of "Tetrahydrocannabinols"), and therefore sales or possession could potentially be prosecuted under the Federal Analogue Act.
HU-211 is a Schedule I controlled substance in
HU-211 is a Schedule I
controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.
Effective January 1, 2016, HU-211 is a regulated drug in Vermont designated as a "Hallucinogenic Drug."
"e-therapeutics Clinical Development Pipeline". Archived from the original on 2013-01-26 . Retrieved . 2012-10-23
Pop E (September 2000). "Nonpsychotropic synthetic cannabinoids". Current Pharmaceutical Design. 6 (13): 1347–60. doi: 10.2174/1381612003399446. PMID 10903397.
Feigenbaum JJ, Bergmann F, Richmond SA, Mechoulam R, Nadler V, Kloog Y, Sokolovsky M (December 1989). "Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker". Proceedings of the National Academy of Sciences of the United States of America. 86 (23): 9584–7. Bibcode: 1989PNAS...86.9584F. doi: 10.1073/pnas.86.23.9584. PMC . 298542 PMID 2556719.
Biegon A, Joseph AB (August 1995). "Development of HU-211 as a neuroprotectant for ischemic brain damage". Neurological Research. 17 (4): 275–80. doi: 10.1080/01616412.1995.11740326. PMID 7477742.
Darlington CL (October 2003). "Dexanabinol: a novel cannabinoid with neuroprotective properties". IDrugs. 6 (10): 976–9. PMID 14534855.
Vink R, Nimmo AJ (January 2009). "Multifunctional drugs for head injury". Neurotherapeutics. 6 (1): 28–42. doi: 10.1016/j.nurt.2008.10.036. PMC . 5084254 PMID 19110197.
Maas AI, Murray G, Henney H, Kassem N, Legrand V, Mangelus M, et al. (January 2006). "Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial". The Lancet. Neurology. 5 (1): 38–45. doi: 10.1016/S1474-4422(05)70253-2. PMID 16361021.
^ University of California, San Diego "
Synthetic Cannabinoid May Be Used as Brain Cancer Treatment". (28 September 2012) Laboratory Equipment. Retrieved 28 September 2012.
"A Phase 1 Study of Dexanabinol in Patients With Advanced Solid Tumours". ClinicalTrials.gov. NIH. January 26, 2015.
"e-Therapeutics Reports Progress in ETS2101 Phase 1a and Oral Dosing Studies" (PDF). 18 December 2014. Archived from the original (PDF) on 5 February 2015.
"Clinical Development Pipeline". Archived from the original on February 5, 2015 . Retrieved . Feb 5, 2015
"A Study of Dexanabinol in Combination With Chemotherapy in Patients With Advanced Tumours - Full Text View - ClinicalTrials.gov". clinicaltrials.gov . Retrieved . 2015-09-18
UN International Drug Control Conventions
§1308.11 Schedule I.
Erowid Analog Law Vault : Federal Controlled Substance Analogue Act Summary
"Alabama Senate Bill 333 - Controlled substances, Schedule I, additional synthetic controlled substances and analogue substances included in, trafficking in controlled substance analogues, requisite weight increased, Secs. 13A-12-231, 20-2-23 am'd". March 2014 . Retrieved . 2 February 2017
Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL
Vermont DOH - Regulated Drug Rule 2016 .PDF