In 1956, on the basis of an inscription dating to 157 BC, Michael Ballance fixed the site of Derbe at a mound known as Kerti Hüyük, some 15 miles (24 km) northeast of Karaman (ancient Laranda), near Ekinözü village in modern day Turkey. Although subject to controversy, this is considered the most likely site.
Claudioderbe was a special title given to Derbe during the reign of the Roman Emperor Claudius; it appears on second century coins from Derbe.
The apostles Paul and Barnabas came to Derbe after escaping a disturbance and attempted stoning in Iconium, about 60 miles away, and successfully evangelized there. Paul and Barnabas returned there after being stoned again in Lystra. On these experiences, Paul commented, "We must through many tribulations enter the kingdom of God." He and Silas later visited Derbe again.