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|Topical (ophthalmic solution)|
|Chemical and physical data|
|Molar mass||716.588 g/mol|
|3D model (JSmol)|
|(what is this?)|
Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.
Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour). As demecarium irreversibly inhibits cholinesterase, it can be administered less frequently than reversible inhibitors, such as carbachol.
When administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs. High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.