Drezner rarely discusses his political loyalties, but in 2011 he wrote: "I find liberals write 'even conservative Dan Drezner...' while conservatives often deploy terms like 'academic elitist' or 'RINO.' In my case, at this point in time, I believe that last appellation to be entirely fair and accurate. I'm not a Democrat, and I don't think I've become more liberal over time."
Drezner supported the 2003 U.S. invasion of Iraq, writing that "a successful invasion not only eliminates the Iraqi threat, but over the long run it reduces the Arab resentment that feeds Al-Qaeda." 
Drezner was a signatory to a March 2016 open letter by Republican national security community members that opposed Donald Trump as Republican nominee for U.S. President. Drezner announced in July 2017 that he is no longer part of the Republican party.
In October 2017, he recommended to Secretary of State Rex Tillerson to resign.
Drezner's 2007 book, All Politics Is Global: Explaining International Regulatory Regimes, looked at international economic regulations and concluded that these were under the control of the most wealthy and powerful nations, as they had been in the past. G. John Ikenberry in Foreign Affairs comments: "His main contribution, however, is to explode a popular notion of globalization and thereby to set an agenda for the study of global regulatory politics. For social movements seeking to shape the governance of the world economy, all roads still lead to the state."
Drezner's 2011 book, Theories of International Politics and Zombies, speculated about different ways the international community might respond to a zombie outbreak, although he "concedes that the statistical probability of such an event is extremely difficult to determine but generally thought to be low." Oliver Stuenkel, writing in Post-Western World, commented: "Drezner’s book is a must-read for young international relations scholars, considering the vast attention this topic is likely to get in the future."
Drezner, Daniel W. (2008), "International economic order", in Darity, William A. (ed.), International encyclopedia of the social sciences, volume 4: Inequality, income – Marxism (2nd ed.), Detroit: Macmillan Reference USA, ISBN9780028659695.
Drezner, Daniel W. (October 2005). "Globalization, harmonization, and competition: the different pathways to policy convergence". Journal of European Public Policy, Special Issue: Cross-national Policy Convergence: Causes, Concepts and Empirical Findings. 12 (5): 841–859. doi:10.1080/13501760500161472.
Drezner, Daniel W. (September 1999). "The trouble with carrots: transaction costs, conflict expectations, and economic inducements". Security Studies, Special Issue: Power and the Purse: Economic Statecraft, Interdependence, and National Security. 9 (1–2): 188–218. doi:10.1080/09636419908429399.