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Cyclic nucleotide-gated channel alpha 1

CNGA1
Identifiers
AliasesCNGA1, CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1
External IDsOMIM: 123825 MGI: 88436 HomoloGene: 55432 GeneCards: CNGA1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CNGA1
Genomic location for CNGA1
Band4p12Start47,935,977 bp[1]
End48,016,672 bp[1]
RNA expression pattern
PBB GE CNGA1 206417 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000087
NM_001142564

NM_007723

RefSeq (protein)

NP_000078
NP_001136036
NP_000078.2

NP_031749

Location (UCSC)Chr 4: 47.94 – 48.02 MbChr 5: 72.6 – 72.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.[5] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.[6] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.[7][8][9] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.[10] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198515 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067220 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". Ncbi.nlm.nih.gov. Retrieved 2016-08-02.
  6. ^ Kaupp, U. Benjamin; Niidome, Tetsuhiro; Tanabe, Tsutomu; Terada, Shoichi; Bönigk, Wolfgang; Stühmer, Walter; Cook, Neil J.; Kangawa, Kenji; Matsuo, Hisayuki (December 1989). "Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel". Nature. 342 (6251): 762–766. doi:10.1038/342762a0. ISSN 0028-0836.
  7. ^ Zheng, Jie; Trudeau, Matthew C.; Zagotta, William N. (December 2002). "Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit". Neuron. 36 (5): 891–896. doi:10.1016/s0896-6273(02)01099-1. ISSN 0896-6273.
  8. ^ Zhong, Haining; Molday, Laurie L.; Molday, Robert S.; Yau, King-Wai (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature. 420 (6912): 193–198. doi:10.1038/nature01201. ISSN 0028-0836. PMC 2877395.
  9. ^ Weitz, Dietmar; Ficek, Nicole; Kremmer, Elisabeth; Bauer, Paul J.; Kaupp, U.Benjamin (December 2002). "Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors". Neuron. 36 (5): 881–889. doi:10.1016/s0896-6273(02)01098-x. ISSN 0896-6273.
  10. ^ Chen, T.-Y.; Peng, Y.-W.; Dhallan, R. S.; Ahamed, B.; Reed, R. R.; Yau, K.-W. (April 1993). "A new subunit of the cyclic nucleotide-gated cation channel in retinal rods". Nature. 362 (6422): 764–767. doi:10.1038/362764a0. ISSN 0028-0836.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.