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Clinical data
SynonymsCortiphen; Kortifen; Fencoron; 11-Deoxycortisol 21-(4-(bis(2-chloroethyl)amino)phenyl)acetate; 11-Desoxy-17α-hydroxy-21-[n-di-2(chlorethyl)aminophenyl acetate]corticosterone
Drug classCytostatic antineoplastic agent; Corticosteroid; Glucocorticoid
PubChem CID
Chemical and physical data
Molar mass604.609 g/mol g·mol−1
3D model (JSmol)

Cortifen, also known as cortiphen or kortifen, as well as fencoron, is a synthetic glucocorticoid corticosteroid and cytostatic antineoplastic agent which was developed in Russia for potential treatment of tumors.[1][2][3] It is a hydrophobic chlorphenacyl nitrogen mustard ester of 11-deoxycortisol (cortodoxone).[1][2][3][4]

See also


  1. ^ a b Lagova ND, Kiselev VI, Kurdiumova KN, Sof'ina ZP, Shkodinskaia EN (1989). "[Experimental study of the antitumor properties and mechanism of action of kortifen]". Vopr Onkol (in Russian). 35 (4): 450–6. PMID 2728387.
  2. ^ a b Oborotov, A. V.; Smirnova, Z. S.; Klochkova, T. I.; Arzamastsev, A. P. (1999). "Biopharmaceutical investigation of a new medicinal form of the antitumor drug cortifen". Pharmaceutical Chemistry Journal. 33 (10): 540–542. doi:10.1007/BF02508377. ISSN 0091-150X.
  3. ^ a b Smirnova, Z. S.; Rodionova, Yu. V.; Khalanskii, A. S.; Gershtein, E. S.; Gerasimova, G. K. (1999). "Dependence of antitumor effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells". Bulletin of Experimental Biology and Medicine. 127 (3): 299–300. doi:10.1007/BF02433363. ISSN 0007-4888.
  4. ^ Oborotova NA, Smirnova ZS, Polozkova ZS, Baryshnikov AIu (2002). "[Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics]". Vestn. Akad. Med. Nauk SSSR (in Russian) (1): 42–5. PMID 11882971.