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Chlorophenylsilatrane

Chlorophenylsilatrane
Chlorophenylsilatrane.svg
Names
IUPAC name
1-(4-Chlorophenyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane
Other names
RS-150
Identifiers
3D model (JSmol)
ChemSpider
Properties
C12H16ClNO3Si
Molar mass 285.80 g·mol−1
Hazards
Main hazards Extremely toxic
Lethal dose or concentration (LD, LC):
1.4 mg/kg (rats, oral)
0.9-2.0 mg/kg (mice, oral)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Chlorophenylsilatrane is an extremely toxic organosilicon compound that was used as a rodenticide.

Chlorophenylsilatrane was one of the toxic chemicals studied in the Project Coast.[1]

Toxicity

Chlorophenylsilatrane is a GABA receptor antagonist.[2] It's a rapid acting convulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[3]

See also

References

  1. ^ "Project Coast, Part One: The mad doctor and the forgotten rat poison". Toxic Terror.
  2. ^ Casida, JE; Lawrence, LJ (September 1985). "Structure-activity correlations for interactions of bicyclophosphorus esters and some polychlorocycloalkane and pyrethroid insecticides with the brain-specific t-butylbicyclophosphorothionate receptor". Environmental Health Perspectives. 61: 123–32. PMC 1568750. PMID 2415350.
  3. ^ Greaves, JH; Redfern, R; Tinworth, H (August 1974). "Laboratory tests of 5-p-chlorophenyl silatrane as a rodenticide". The Journal of Hygiene. 73 (1): 39–43. PMC 4529452. PMID 4529452.