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Chloride channel blocker

A chloride channel blocker is a type of drug which inhibits the transmission of ions (Cl) through chloride channels.

Niflumic acid is a chloride channel blocker that has been used in experimental scientific research.[1] Another example is anthracene-9-carboxylic acid, a potent blocker of the CLCN1-type chloride channel found in skeletal muscle, which is used to study animal models of myotonia congenita.[2]

See also

References

  1. ^ Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917.
  2. ^ Villegas-Navarro A, Martinez-Morales M, Morales-Aguilera A (March 1986). "Pharmacokinetics of anthracene-9-carboxylic acid, a potent myotonia-inducer". Archives Internationales de Pharmacodynamie et de Thérapie. 280 (1): 5–21. PMID 3718080.

Further reading