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CatSper4

CATSPER4
Identifiers
AliasesCATSPER4, CatSper4, cation channel sperm associated 4
External IDsOMIM: 609121 MGI: 3043288 HomoloGene: 18638 GeneCards: CATSPER4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CATSPER4
Genomic location for CATSPER4
Band1p36.11Start26,190,561 bp[1]
End26,202,968 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198137

NM_001130030
NM_177866

RefSeq (protein)

NP_937770

NP_001123502
NP_808534

Location (UCSC)Chr 1: 26.19 – 26.2 MbChr 4: 134.21 – 134.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene.[5][6][7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188782 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048003 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.
  6. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.
  7. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
  8. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.