|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||365.47 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Caroverine (Spasmium, Tinnitin, Tinnex) is a muscle-relaxing drug used in Austria and Switzerland to relieve spasms in smooth muscles (which include intestines, arteries, and other organs), and the use in those countries was extended to aid with cerebrovascular diseases there, and eventually to treat tinnitus. It is also used to treat tinnitus in India.
Its INN name, caroverine, was proposed in 1972.
An intravenous formulation was tested in a single-blinded study in tinnitus that published in 1997 and had positive results; an effort to replicate those results failed to show any effect, and more people had their condition worsen than experienced benefit. Pilot studies using a spray formulation for tinnitus published in 2005.
In 2010 Phafag licensed rights to caroverine to the Indian company, Lincoln Pharmaceuticals, to develop the drug for tinnitus in India. Lincoln first marketed it for that purpose in India in 2011.
As of 2018 it was marketed under the brand names Spasmium and Tinnitin in Austria, and under the brand Tinnex in India.