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Skeletal formula of cafaminol
Ball-and-stick model of the cafaminol molecule
Clinical data
Trade namesRhinetten, Rhinoptil
SynonymsMethylcoffanolamine; 8-[(2-Hydroxyethyl)(methyl)amino]caffeine
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.045.795 Edit this at Wikidata
Chemical and physical data
Molar mass267.28 g/mol g·mol−1
3D model (JSmol)

Cafaminol (brand names Rhinetten, Rhinoptil), also known as methylcoffanolamine, is a vasoconstrictor and anticatarrhal of the methylxanthine family related to caffeine which is used as a nasal decongestant in Germany.[1][2][3][4][5][6] It was introduced in 1974 and was still in use as of 2000.[3][2]


  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 205–. ISBN 978-1-4757-2085-3.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 157–. ISBN 978-3-88763-075-1.
  3. ^ a b William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 784–. ISBN 978-0-8155-1856-3.
  4. ^ Szirmai E (1969). "[A new treatment for colds using a new caffeine derivative, methylcoffanolamine]". Praxis (in German). 58 (13): 412–4. PMID 5818666.
  5. ^ Walther H, Köhler E (1979). "[Human pharmacologic studies on the biologic availability and resorption of cafaminol (AWD) (proceedings)]". Pharmazie (in German). 34 (5–6): 375–6. PMID 515164.
  6. ^ Rogowski M, Chodynicki S (1985). "[Use of the preparation Cafaminol in the treatment of acute rhinitis]". Wiad. Lek. (in Polish). 38 (20): 1437–40. PMID 3913153.