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CP-94253 structure.png
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass257.330 g/mol g·mol−1
3D model (JSmol)
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CP-94253 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain;[2][3] reducing food intake and promoting satiety;[4][5][6] enhancing the reinforcing effects of cocaine;[7][8][9][10] and possible antidepressant effects.[11]


  1. ^ Koe KB, Nielsen JA, Macor JE, Heym J. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research. 1992;26(3):241-250. doi:10.1002/ddr.430260305
  2. ^ Monti JM, Monti D, Jantos H, Ponzoni A. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. Neuropharmacology. 1995 Dec;34(12):1647-51. PMID 8788962
  3. ^ Iyer RN, Bradberry CW. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. Journal of Pharmacology and Experimental Therapeutics. 1996 Apr;277(1):40-7. PMID 8613947
  4. ^ Halford JC, Blundell JE. The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiology & Behavior. 1996 Sep;60(3):933-9. PMID 8873272
  5. ^ Lee MD, Simansky KJ. CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology. 1997 Jun;131(3):264-70. PMID 9203237
  6. ^ Lee MD, Kennett GA, Dourish CT, Clifton PG. 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Psychopharmacology. 2002 Oct;164(1):49-60. PMID 12373419
  7. ^ Parsons LH, Weiss F, Koob GF. Serotonin1B receptor stimulation enhances cocaine reinforcement. Journal of Neuroscience. 1998 Dec 1;18(23):10078-89. PMID 9822762
  8. ^ Przegalinski E, Filip M, Papla I, Siwanowicz J. Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats. Behavioural Pharmacology. 2001 Apr;12(2):109-16. PMID 11396515
  9. ^ Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M (March 2007). "Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats". European Journal of Pharmacology. 559 (2–3): 165–72. doi:10.1016/j.ejphar.2006.12.012. PMID 17291490.
  10. ^ Przegaliński E, Gołda A, Filip M (2008). "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports : PR. 60 (6): 798–810. PMID 19211971.
  11. ^ Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. European Journal of Pharmacology. 2005 May 23;516(1):46-50. PMID 15913599